Antigen-Antibody Complex (Immune Complex)

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Also Known As:

Immune Complex; Antigen-Antibody Complexes; Immune Complexes; Antigen Antibody Complex; Antigen Antibody Complexes; Complex, Antigen-Antibody; Complex, Immune; Complexes, Antigen-Antibody; Complexes, Immune

Networked: 12205 relevant articles (344 outcomes, 852 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Novak, Jan: 37 articles (03/2024 - 08/2002)
2.	Julian, Bruce A: 31 articles (01/2023 - 08/2002)
3.	Anders, Hans-Joachim: 26 articles (01/2020 - 05/2001)
4.	Sethi, Sanjeev: 25 articles (03/2024 - 05/2009)
5.	Fervenza, Fernando C: 23 articles (03/2024 - 02/2006)
6.	Suzuki, Hitoshi: 23 articles (01/2022 - 03/2006)
7.	Ronco, Pierre: 19 articles (01/2024 - 11/2003)
8.	Monteiro, Renato C: 18 articles (03/2024 - 12/2003)
9.	Mestecky, Jiri: 18 articles (01/2023 - 08/2002)
10.	Tomino, Yasuhiko: 18 articles (01/2019 - 03/2003)

Related Diseases

1.	Glomerulonephritis 10/01/2005 - "Perhaps the best treatment for glomerulonephritis is the identification and correction of any underlying inflammatory, immune-mediated or neoplastic disease that results in the deposition or formation of glomerular immune complexes. " 01/01/1996 - "Glomerular structural damage expressed as glomerular damage index was significantly greater in rats with immune complex glomerulonephritis when compared with controls (immune complex glomerulonephritis 0.91 +/- 0.13; control 0.60 +/- 0.08; P < 0.05), but was uneffected by the treatment with the CEI (immune complex) glomerulonephritis + CEI 1.02 +/- 0.26; control + CEI 0.63 +/- 0.11). " 11/22/2003 - "Assuming that a decrease in CD2AP attenuates clearance of glomerular immune complexes, patients with other types of idiopathic glomerulonephritis should also have a CD2AP mutation. " 07/01/1982 - "Impairment of glomerular clearance of macroaggregates in immune complex glomerulonephritis." 10/01/2022 - "The present study identified a novel renoprotective role of ACE in glomerulonephritis; elevated neutrophilic ACE promotes elimination of locally formed ICs in glomeruli via C3b-CR1/2 and FcγRII/III, ameliorating glomerular injury.NEW & NOTEWORTHY We studied immune complex (IC)-mediated crescentic glomerulonephritis in NeuACE mice that overexpress ACE only in neutrophils. "
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/2016 - "Great progress has been made in the last decades in understanding the complex immune dysregulation in systemic lupus erythematosus (SLE), yet the efforts to pursue an effective treatment of SLE proved to be futile. " 01/01/2013 - "Abnormalities in complement activation and clearance of immune complexes by erythrocytes are the central pathogenic mechanisms in systemic lupus erythematosus (SLE). " 12/01/2005 - "Hypocomplementaemia and low expression of CR1 on erythrocytes (E) of patients with systemic lupus erythematosus (SLE) are associated with defective clearance of circulating immune complexes (IC) and so they may have pathogenic significance. " 12/01/2000 - "Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes." 01/01/2014 - "Despite rapid accumulation of knowledge about complex immune dysregulation in systemic lupus erythematosus (SLE) and major primary lupus syndromes, and a plethora of promising new treatments reaching preclinical and early clinical studies, advanced-phase trials of new biologic agents have repeatedly failed to achieve their clinical end points. "
3.	Proteinuria 10/01/2008 - "Mice treated with CoPP displayed a significant reduction in proteinuria and a marked amelioration of glomerular lesions, accompanied by attenuated immune-complex deposition. " 11/01/2019 - "Atializumab significantly diminished proteinuria, improved glomerular and tubular damages and reduced the renal deposition of immune-complexes. " 12/19/2017 - " did not exhibit significant reduction of proteinuria, amelioration of glomerular lesions, or attenuation of immune complex deposition. " 11/01/1977 - "A control group of 20 immunized rats, also observed for 13 weeks, did not receive MS. MS treatment significantly decreased the incidence of heavy proteinuria (p less than 0.001), the severity of proteinuria at each week throughout the course of the disease (p less than 0.001), the amount of immune complex deposition in the glomeruli, and also delayed the onset of proteinuria (p less than 0.001). " 08/01/2023 - "Since immune complexes within the kidney often require a long time to be degraded, proteinuria response can follow the immunological remission after many months. "
4.	Infections 01/01/2016 - "Infection with Plasmodium chabaudi diminishes plasma immune complexes and ameliorates the histopathological alterations in different organs of female BWF1 lupus mice." 07/01/1993 - "Pathogenesis can be related to occult infection, loss of mucosal barrier function, defective clearance of immune complexes, or aberrant immune responses. " 07/01/1993 - "An alternative hypothesis is the possible role of defective clearance of immune complexes in the development of severe infections. " 01/01/2018 - "To study the Ab-mediated entry of DENV, the experimental conditions for enhancement of infection were established by inoculating immune complexes formed with DENV-2 and the Ab 2H2 or 3H5. " 01/01/2017 - "This study elucidates the regulatory role of AS for the immune complex under systemic APEC infection."
5.	Inflammation (Inflammations) 01/01/2023 - "Our results indicate that complex immune regulation mechanism control the course of AP, where moderate pro-inflammation not necessarily associates with increased disease severity but also drives tissue regenerative processes through a more effective clearance of necrotic acinar cells. " 01/01/2018 - "The classical pathway contributes to the clearance of immune complexes (ICs) and apoptotic cells, whereas the alternative pathway (AP) exacerbates renal inflammation. " 09/01/2010 - "One possible mechanism to explain the association between reduced FCGR3B CN and RA is the reduced clearance of immune complex during inflammation. " 07/01/1983 - "The correlation of a improvement in clinical response and a decrease in the levels of immune complexes or other factors of inflammation was observed. " 04/30/2018 - "However, the maturity of this cell may be altered. Future study in the understanding of neutrophil-mediated inflammation, particularly related to immune complexes and functionality, is imperative to be explored."

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Complement System Proteins (Complement)
3.	Antibodies
4.	Immunoglobulin A (IgA)
5.	Autoantibodies
6.	Antigens
7.	Cytokines
8.	Vaccines
9.	Immunoglobulin M (IgM)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Plasmapheresis
3.	Immunotherapy
4.	Plasma Exchange
5.	Drug Therapy (Chemotherapy)