Alanine Transaminase (SGPT)

An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.

Also Known As:

SGPT; Glutamic Pyruvic Transaminase; Alanine-2-Oxoglutarate Aminotransferase; Glutamic-Alanine Transaminase; Alanine 2 Oxoglutarate Aminotransferase; Aminotransferase, Alanine; Aminotransferase, Alanine-2-Oxoglutarate; Glutamic Alanine Transaminase; Transaminase, Alanine; Transaminase, Glutamic-Alanine; Transaminase, Glutamic-Pyruvic; Alanine Aminotransferase; Glutamic-Pyruvic Transaminase; L-Alanine:2-oxoglutarate aminotransferase

Networked: 13044 relevant articles (487 outcomes, 904 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Nitrogenous Group Transferases
      - Transaminases: 11235
        Alanine Transaminase: 13044

Experts

1.	Kao, Jia-Horng: 39 articles (04/2024 - 01/2003)
2.	Zhang, Li: 36 articles (02/2024 - 11/2008)
3.	Wang, Wei: 31 articles (04/2024 - 02/2003)
4.	Wong, Vincent Wai-Sun: 30 articles (02/2023 - 02/2005)
5.	Ahn, Sang Hoon: 29 articles (02/2024 - 03/2009)
6.	Li, Jing: 27 articles (03/2024 - 12/2015)
7.	Wang, Jian: 26 articles (06/2024 - 11/2006)
8.	Kleiner, David E: 26 articles (03/2024 - 02/2004)
9.	Chen, Pei-Jer: 25 articles (04/2024 - 01/2003)
10.	Wong, Grace Lai-Hung: 25 articles (02/2023 - 12/2008)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2020 - "While a higher alanine transaminase (ALT) level at presentation is a significant predictor of remission, a lower ALT level and cirrhosis are significant risk factors for unfavourable outcome. " 08/01/2017 - "The LSM in patients with high alanine aminotransferase levels or high body mass index was associated with false positive results regarding advanced fibrosis. " 03/01/2019 - "The primary study endpoint was improvement in alanine transaminase (ALT) levels, secondary endpoints were improvement in steatosis score and improvement in fibrosis score. " 04/01/2023 - "Alanine aminotransferase levels improved even in patients not achieving a virologic response, including five patients who had decompensated cirrhosis at the start of treatment. " 01/31/2024 - "This study aimed to investigate independent factors and profiles associated with significant hepatic fibrosis, including alanine aminotransferase (ALT) levels >30 U/L and metabolic dysfunction-associated SLD (MASLD), in health check-up examinees. "
2.	Body Weight (Weight, Body) 09/01/2003 - "Whereas, when rats were fed on LCD protocol, their body weight (329.5+/-38.4 g, P<0.01), abdominal adipose content (310.21+/-1.52 g, P<0.05), liver index (3.199+/-0.552 %, P<0.05), and serum alanine aminotransferase (683.03+/-245.49 nkat/L, P<0.05) were significantly decreased, and the degree of hepatic steatosis (P<0.05) was markedly improved compared with those in the NASH group. " 06/01/2008 - "Alanine aminotransferase significantly improved from baseline with decreasing body weight in both groups (MET: 35 [range, 21-43] to 32 [20-46] U/L; control: 66 [28-121] to 33 [14-45] U/L; P<or=0.01). " 11/01/1990 - "For every 1% reduction in body weight, alanine aminotransferase activity improved by 8.1%. " 12/01/2023 - "The reference point for phenylcapsaicin derived from a 90-day repeated dose oral toxicity study in rats is 37.2 mg/kg body weight (bw) per day, the lowest of the model averaged BMDL20 values for alanine aminotransferase increase in plasma. " 01/09/2024 - "Dietary MSC + MSM decreased (P < 0.001) feed intake (FI), body weight gain (BWG), and feed conversion efficiency (FCE); slaughter weight, hot carcass weight (HCW), cold carcass weight (CCW), breast weight, and back lengths (P < 0.001); serum SDMA and alanine transaminase (P < 0.05). "
3.	Non-alcoholic Fatty Liver Disease 06/01/2013 - "Application of a QC/isoQC inhibitor led to a significant reduction in circulating alanine aminotransferase and NAFLD activity score accompanied by an inhibitory effect on hepatocyte ballooning. " 01/01/2015 - "A total of 15 middle-aged obese women with NAFLD who had no improvement in serum alanine aminotransferase levels and/or liver fat deposition after 12 weeks of lifestyle counseling participated in an HYB program. " 12/01/2008 - "To compare various treatment options provided to patients with Nonalcoholic Steatohepatitis (NASH) and assess improvement in liver status via reduction in serum Alanine Aminotransferase (ALT) levels. " 05/09/2024 - "This study aimed to correlate the ultrasound-based diagnosis of MAFLD with the histological diagnosis of nonalcoholic steatohepatitis (NASH) and alanine aminotransferase (ALT) levels in patients with MAFLD. " 01/01/2023 - "We conducted a Mendelian randomization (MR) study using genetic predictors of alanine aminotransferase (ALT), NAFLD, and percent liver fat (PLF) and combined them with genome-wide association study (GWAS) summary statistics from the ENIGMA Consortium. "
4.	Insulin Resistance 10/01/2003 - "Five patients withdrew early; the 25 patients completing 48 weeks of treatment had significantly improved insulin sensitivity and mean serum alanine aminotransferase (ALT) levels (104 initially, 42 U/L at the end of treatment). " 01/01/2021 - "Although TZD increase insulin sensitivity and partially reduce steatosis and alanine aminotransferase, the efficacy of TZD on resolving liver pathology is limited. " 01/01/2007 - "The aim of our study was to study the influence of insulin resistance in obese patients on elevated serum alanine aminotransferase. " 10/01/2023 - "Accordingly, hepatic insulin sensitivity was impaired and circulating alanine aminotransferase level increased. " 01/01/2023 - "Independent predictors of sustained stabilization were the change in beta-cell function during induction and changes in hepatic insulin resistance and alanine aminotransferase during maintenance. "
5.	Inflammation (Inflammations) 09/01/2020 - "Alanine aminotransferase, a marker of hepatic inflammation, significantly improved. " 11/01/2004 - "MCD diet-fed db/db mice exhibited significantly greater histological inflammation and higher serum alanine aminotransferase levels than db/m and ob/ob mice. " 02/01/2001 - "Serum levels of these immunological parameters did not correlate with serum alanine aminotransferase (ALT) when evaluated with either absolute values or relative values (over pre-treatment value), implying that our results are not just secondary to improvement in hepatic inflammation. " 02/15/2024 - "Besides, it improved hepatic inflammation as well, including a decrease in serum alanine aminotransferase and a reduction in macrophage and neutrophil infiltration. " 06/01/2023 - "Biochemical remission was defined as an alanine aminotransferase (ALT) level below 40 U/l and histological remission was defined as a situation when the control biopsy revealed inflammation grade G1 (or lower) in the Batts-Ludwig score. "

Related Drugs and Biologics

1.	Aspartate Aminotransferases (Aspartate Transaminase)
2.	Bilirubin
3.	Triglycerides (Triacylglycerol)
4.	Alkaline Phosphatase
5.	Cholesterol
6.	Glucose (Dextrose)
7.	Enzymes
8.	DNA (Deoxyribonucleic Acid)
9.	Creatinine
10.	Albumins

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Length of Stay
4.	Liver Transplantation
5.	Bariatric Surgery