Congenital Abnormalities (Deformity)

02/23/2019 - "This was reversed by the maternal supply with folic acid (3 mg/kg/day) during the last third of gestation, resulting in a significant reduction of associated birth defects. "
06/15/2005 - "Based upon suggestive evidence that periconceptional folic acid supplementation is effective in preventing a significant proportion of the aforementioned birth defects, genetic variation in the folate biosynthetic pathways may influence the infant's susceptibility to these birth defects. "
01/01/2024 - "Results from multistate NBDPN publications have provided critical information not available through other sources, including US prevalence estimates of major birth defects, folic acid fortification and NTD prevention, and improved understanding of defect trends and surveillance efforts. "
11/01/2000 - "Furthermore, it would require changes to the previous recommendations since a multivitamin containing a physiological dose of folic acid (0.5 to 0.8mg) seems to be more effective in reducing the occurrence of the first NTD and other congenital abnormalities than folic acid alone. "
09/01/2018 - "In the present study, we attempted to determine the possible protective effects of exogenous folate on LTG-induced fetal anomalies in TO mouse. "

11/01/2001 - "This study presents a practical classification that permits the plastic surgeon to critically evaluate which is the best option to correct abdominal deformities considering specific areas of myoaponeurotic weakness."
09/01/2001 - "This study presents a practical classification that permits the plastic surgeon to critically evaluate which is the best option to correct abdominal deformities considering specific skin and subcutaneous deformities."
01/01/2024 - "Of those that responded, comfort in facial nasal analysis, identification of common nasal deformities, surgical planning, and development of an overall surgical plan were significantly improved after completion of the facial plastic rotation. "
05/01/2023 - "Furthermore, open fixation surgery for LHCF rectification before fixing the ulnar deformity with the aid of a suitable maneuver led to good outcome and acceptable rehabilitation in a case of concurrent ulnar plastic deformity and an ipsilateral fracture of the external condyle of the humerus. "
04/01/2024 - "Three-dimensional printing of plastic 3D models was feasible (all patients, 100%) and was considered helpful for deformity analysis by the treating surgeons for severe and moderate SCFE. "

10/01/2018 - "Our results reflect the efficacy of flexible titanium eight plate which corrects angular deformity by acting as a tension band on one side of the growth plate and offers the advantage of reversible Hemi epiphyseal growth modulation. "
07/01/2015 - "To derive an objective measure of parasol rib deformity from spine radiographs and to compare efficacy of rib-based (vertical expandable prosthetic titanium rib (VEPTR)) versus spine-based growing rods ("GR") instrumentation to improve parasol rib deformity and pulmonary function. "
02/01/2011 - "The aim of this work is to evaluate the efficacy of using a titanium mesh cage compared to iliac crest grafting regarding correction of the deformity, fusion rate and to report the incidence of complications. "
04/01/2010 - "In the last decade, the use of growing rods and vertebral expandable prosthetic titanium rib has improved the armamentarium of the spinal surgeon in dealing with certain difficult congenital spinal deformities. "
07/01/2009 - "Efficacy of intraoperative neurologic monitoring in surgery involving a vertical expandable prosthetic titanium rib for early-onset spinal deformity."

01/01/1982 - "Previously recommended treatment programs of high doses of vitamin D have effected some roentgenographic improvement in the rachitic lesions, but no related increase in height or severity of deformities has been associated with significant complications resulting from vitamin D toxicity. "
01/01/2018 - "Vitamin D supplementation during pregnancy is associated with a reduced risk of SGA and improved infant growth without risk of fetal or neonatal mortality or congenital abnormality. "
01/01/2023 - "Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study."
03/07/2018 - "This study demonstrates that decreased maternal dietary vitamin-D intake during pregnancy increases the risk of spinal deformity in offspring. "
01/01/2018 - "Vitamin D supplementation during pregnancy was associated with a lower risk of SGA (RR, 0.72; 95% CI, 0.52 to 0.99; RD, -5.60%; 95% CI, -0.86% to -10.34%) without risk of fetal or neonatal mortality (RR, 0.72; 95% CI, 0.47 to 1.11) or congenital abnormality (RR, 0.94; 95% CI, 0.61 to 1.43). "

11/01/2011 - "This non-prosthetic pectus deformity repair was effective with low serious morbidity and high patient satisfaction without the inherent disadvantages of using a metal bar."
08/01/2007 - "The efficacy of Nesplon tape in correction of deformity is equivalent to that of metal wire, and fusion was completed without significant correction loss. "
03/01/2013 - "Systems biology-based approaches may help to identify key pathways that mediate metal-induced birth defects as well as potential targets for prevention. "
08/01/2023 - "In conclusion, this study provides consistent data of soil toxicity, metal and REE contamination at Augusta-Priolo sampling sites, and may provide an appropriate baseline for epidemiological studies on high incidences of congenital birth defects in the area and identification of at-risk localities."
08/01/2023 - "The aim of this study was to determine whether a metal augment can correct the glenoid deformity in an anatomic manner. "

07/01/2011 - "Thalidomide: the tragedy of birth defects and the effective treatment of disease."
10/16/2017 - "In this study, we challenged the developing embryo at the stage of blood island formations (HH8), which is the most vulnerable stage for thalidomide-induced deformities. "
06/18/2013 - "However, the discovery of thalidomide-induced birth defects and many later studies afterwards proved the opposite. "
12/01/2012 - "We retrospectively analyzed the reproductive variables and the spontaneous malformations in the historical control data from the embryo-fetal development studies conducted in our laboratories with Kbl:JW rabbits over two decades (1990-2010) and fetal malformations induced by thalidomide in 1988, 1995 and 2007. "
01/01/2012 - "This study confirms that NO reduced the number of thalidomide mediated limb deformities by 94% and 80% in chick and zebrafish embryos respectively. "

01/01/2020 - "On follow-up 36% of the patients showed complete or significant improvement in leg deformities and these patients had similar phosphate levels at presentation with better levels in 1st and 2nd years of treatment; even the treatment doses of phosphate were similar. "
01/01/2022 - "All HR patients recruited in this study displayed bone deformities and tooth agenesis, as well as reduced serum phosphate levels and elevated urine phosphate levels. "
03/01/2023 - "Compared with patients without vertebral deformity, those with vertebral deformity had a higher male/female ratio, longer disease duration, more height loss, lower serum phosphate, higher bone turnover markers, lower TBS, lower areal bone mineral density (aBMD), lower peripheral volumetric BMD (vBMD) and worse microstructure. "
01/01/2022 - "Intervention to restore phosphate levels early in life during the critical stages of skeletal development in children with XLH could optimize growth and may prevent or reduce bone deformities in childhood. "
11/01/2010 - "Clinical sequelae of inherited disorders that are associated with increased urinary phosphate excretion are deleterious and can lead to abnormal skeletal growth and deformities. "

12/01/2005 - "However, further research on the accuracy of vertebral deformity ascertainment from routine clinical radiographs and on the efficacy of amino-bisphosphonate drugs for reducing the risk of non-vertebral fractures in osteopenic women is needed to define more precisely the subset of osteopenic post-menopausal women in whom use of spinal radiographs is most cost-effective."
12/01/2021 - "In this clinical case, early treatment with bisphosphonates was effective for the treatment of JPD skeletal deformities. "
05/01/2004 - "Intensive bisphosphonate treatment prevented the development of deformity and disability and improved hearing in this child with IH. "
01/01/1990 - "Improvement in the deformity of the face in Paget's disease treated with diphosphonates."
01/01/1990 - "These studies suggest that the long-term control of disease activity attained with diphosphonates, results in the improvement of skeletal deformity."

01/01/2018 - "The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. "
01/01/2018 - "Therefore, the aim of this study was to determine the burden of CRS-related birth defects and its incidence in the pre-vaccine era in Amhara Regional State, Ethiopia. "
04/01/2017 - "Our algorithms can efficiently identify many major structural birth defects in large healthcare datasets and can be used in studies evaluating the safety of vaccines administered to pregnant women. "
04/01/2017 - "We present definitions and prevalence estimates for major structural birth defects to be used in studies of maternal vaccine safety. "
11/01/2015 - "Neither adjuvanted (OR 1.06, 0.95-1.20; five studies; I2=18.8) nor unadjuvanted vaccines (OR 0.89, 0.75-1.04; seven studies; I2=22.6) were associated with an increased risk for congenital defects. "

01/01/1988 - "Therefore, some reduction of disc deformity size, but not necessarily complete reduction, is necessary for a good result, and the enzyme is not as effective in patients with long-standing symptoms."
03/01/2005 - "This study demonstrates that bioactive enzymes and splinting can be effective in correcting ear deformities in a rabbit model."
08/01/2023 - "To our knowledge, there is currently no study in the literature regarding the abnormal elevation of serum levels of hepatobiliary enzymes after surgery to correct the deformity. "
07/01/2021 - "During the study, larval performance (including survival, growth performance, swim bladder inflation effectiveness, deformity rate), the expression of genes involved in immune and stress response, and the specific activity of oxidative stress enzymes (during MRT only) were analyzed. "
09/01/2013 - "Studies in fish have demonstrated that Cd-exposure produce skeletal deformities and alterations in tissue morphology, enzyme activities, stress response, ion regulation and immune response. "

07/01/2022 - "When performed as a staged procedure, TID allows accurate assessment of neurologic function with the patient awake and moving.TID is most effective for severe scoliotic multisegment deformities rather than short rigid curves, which are better treated by osteotomies. "
12/01/2020 - "Le Fort I osteotomy is a highly effective treatment for skeletal jaw deformities and is commonly performed. "
03/01/2017 - "Despite being complex and aggressive procedures, prone to various complications, osteotomies with resection of the three columns are highly effective in the correction of rigid kyphotic deformities and safe enough to justify its use in selected cases. "
01/01/2005 - "Lamella and complex osteotomies of orbital rim and wall were proved to be save and effective for correction of most deformities of the orbital and periorbital region."
09/01/2003 - "Lamella and complex osteotomies of orbital rim and wall are proved to be safe and effective to correct most deformities of orbital and periorbital region and various kinds of orbital malposition."

10/01/2012 - "Splinting therapy of congenital auricular deformities is very effective when initiated within the first 3 days of life while cartilage is quite malleable. "
04/01/2012 - "Until recently, there have been very good results reported in literature when minimally invasive therapy is used to treat this deformity. "
03/01/2012 - "In all the patients, the therapy used was effective, with complete remission of symptoms, without complications or deformities of the forefoot. "
01/01/2012 - "The present investigation confirm results of a previous study demonstrating the efficacy of under-foot wedge use in leg asymmetry correction, posture re-balancing and spine deformities reduction, pointing out the significant contribution of the 3D opto-electronic measurement approach in the critical process of assessing the correct under-foot wedge size, therapy planning and monitoring."
01/01/2024 - "After surgical therapy, a significant reduction of the traumatic kyphotic deformity was shown with an improvement of all angles (vertebral body angle: 3.2° ± 4.4°, mono- and bi-segmental wedge angle: 3.1° ± 5.6°, 2.0° ± 6.3°). "

10/01/2017 - "This study demonstrates excellent patient-eported outcomes with minimal symptomatic complications making the "Toe Grip" implant a safe and effective alternative fixation device for IPJ arthrodesis when dealing with painful digital deformities. "
06/01/2009 - "Correction of these deformities and stabilization with ESF and intratarsal arthrodesis can yield an excellent functional outcome, with improved gait and ambulation."
03/15/2024 - "Tibiotalocalcaneal arthrodesis has been shown in literature to have good results in regards to low complication rates and deformity correction. "
05/01/2015 - "Both groups demonstrated a statistically significant reduction in deformity and a return to more normal radiographic findings after arthrodesis (p < .05). "
08/01/2009 - "The results indicate good long-term correctional effect on valgus deformity after Grice arthrodesis, as the talo-calcaneal and talo-first-metatarsal angles improved significantly. "

04/01/2010 - "Iso-C3D based navigation has been reported to improve the accuracy of pedicle screw placement, however, there are very few studies assessing its efficacy in the presence of deformity. "
12/01/2005 - "Improved deformity correction and overall construct rigidity are two important advantages of pedicle screw instrumentation due its three-column control over the spinal elements. "
02/01/2014 - "We found that the application of posterior instrumentation using pedicle screw and rod resulted in a reasonable correction of the deformity with a significant reduction in recumbency-associated complications; the limiting factor being the small study group and short follow-up period."
01/01/2015 - "In 2013 Lykissas et al, reported that costoplasty combined with pedicle screws and vertebral derotation significantly improved RH deformity as opposed to pedicle screws and vertebral derotation alone. "
03/01/2014 - "The ability to combine 3D imaging with intraoperative navigation systems has improved the accuracy and safety of pedicle screw placement, especially in more complex spinal deformities. "

01/01/2023 - "In medial unicompartmental knee arthroplasty (UKA), the best results and the highest survivorship are found by mild undercorrection of varus deformities. "
01/01/2019 - "Total knee arthroplasty in patients with important axial deformities is a confirmed, reliable, patient-friendly and predictable good outcome procedure."
08/01/2005 - "Total knee arthroplasty in ankylosed knees can achieve correction of deformity with a significant gain in range of motion and marked improvement in quality of life."
01/01/2019 - "In literature, good outcomes are reported for total knee arthroplasty (TKA) in varus deformity. "
11/01/1998 - "A painful arthritic knee with severe valgus deformity may be treated successfully with total knee arthroplasty using several techniques: constrained implant with lateral release, nonconstrained implant with lateral release and a thick tibial insert, or nonconstrained implant with lateral release and medial reconstruction. "