Induction of ovulation with the use of a starting dose of 50 units of recombinant human follicle-stimulating hormone (Puregon).

Abstract

OBJECTIVE:

To determine whether a starting dose of 50 units of recombinant FSH (follitropin beta, Puregon; Organon Laboratories Limited, Cambridge, United Kingdom) produces a follicular response in patients with clomiphene citrate-resistant polycystic ovary syndrome (PCOS).

DESIGN:

Prospective observational study.

SETTING:

Routine clinical practice in a teaching hospital fertility unit.

PATIENT(S):

Patients with clomiphene citrate-resistant PCOS who wanted to become pregnant.

INTERVENTION(S):

Low-dose step-up protocol of SC recombinant FSH administration, monitored prospectively by transvaginal ultrasonography and retrospectively by serum endocrine assays taken at each monitoring visit.

MAIN OUTCOME MEASURE(S):

Rate and size of follicular growth, recombinant FSH requirement, E2 response, ovulation, cycle cancellation, and pregnancy.

RESULT(S):

All patients exhibited a follicular response: Six patients ovulated, of whom two conceived and four had their cycles cancelled because of overstimulation. One patient did not ovulate despite the development of a follicle.

CONCLUSION(S):

Recombinant FSH can be used successfully to stimulate follicular growth at a starting dose of 50 IU.

• Authors: C J Hayden, A J Rutherford, A H Balen
• Journal: Fertility and sterility (Fertil Steril) Vol. 71 Issue 1 Pg. 106-8 (Jan 1999) ISSN: 0015-0282 [Print] United States
• PMID: 9935125 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Fertility Agents, Female
• Follicle Stimulating Hormone, Human
• Recombinant Proteins
• Clomiphene
• Estradiol
• Follicle Stimulating Hormone

Topics

• Adult
• Clomiphene (pharmacology)
• Drug Resistance
• Estradiol (pharmacology)
• Female
• Fertility Agents, Female (pharmacology)
• Follicle Stimulating Hormone (pharmacology)
• Follicle Stimulating Hormone, Human
• Humans
• Ovarian Follicle (drug effects)
• Ovulation Induction
• Polycystic Ovary Syndrome (physiopathology)
• Prospective Studies
• Recombinant Proteins (pharmacology)
• Retrospective Studies
• Stimulation, Chemical