Abstract | OBJECTIVE: METHODS: The radiopharmaceutical technetium 99mTc-P829 was utilized for scintigraphy including single photon emission computed tomography. Thirty individuals with indeterminate SPNs of > or = 1 cm and significant risk factors for primary lung cancer were identified and underwent P829 scintigraphy. Tissue diagnosis was then established by transthoracic needle biopsy specimens. RESULTS: Fourteen subjects demonstrated abnormal P829 scans in the region of the radiographic abnormality. Twelve of this group had biopsy specimens revealing neoplasia. Two subjects with necrotizing granuloma on biopsy specimen had abnormal P829 scans in the region of the nodule. Sixteen subjects had no abnormal P829 tracer uptake in the region of the nodule. Fourteen subjects had benign diagnoses on biopsy specimens. One member of this group with a non-diagnostic biopsy specimen refused thoracotomy and remains radiographically stable at 24 months of follow-up. One subject with a squamous cell carcinoma demonstrated no P829 activity in the region of the nodule. The specificity of P829 scintigraphy based on transthoracic needle biopsy specimen was 88%. The sensitivity was 93%. P829 scintigraphy correctly identified or excluded malignancy in 27 of 30 subjects. CONCLUSIONS: P829 scintigraphy reliably identified or excluded malignancy in radiographically indeterminate solitary pulmonary nodules. The sensitivity and specificity compared favorably with the reported results of F-18 fluorodeoxyglucose positron emission tomographic imaging.
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Authors | J E Blum, H Handmaker, N A Rinne |
Journal | Chest
(Chest)
Vol. 115
Issue 1
Pg. 224-32
(Jan 1999)
ISSN: 0012-3692 [Print] United States |
PMID | 9925088
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Peptides, Cyclic
- Radiopharmaceuticals
- Receptors, Somatostatin
- Technetium
- P 829
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Topics |
- Adult
- Aged
- Biopsy
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, pathology)
- Carcinoma, Small Cell
(diagnostic imaging, pathology)
- Contrast Media
- Female
- Humans
- Lung
(diagnostic imaging, pathology)
- Lung Neoplasms
(diagnostic imaging, pathology)
- Male
- Middle Aged
- Peptides, Cyclic
- Radiopharmaceuticals
- Receptors, Somatostatin
(analysis)
- Sensitivity and Specificity
- Solitary Pulmonary Nodule
(diagnostic imaging, pathology)
- Technetium
- Tomography, Emission-Computed, Single-Photon
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