Alterations in plasma sialyltransferase associated with successful chemotherapy of a disseminated tumor. Case report.

Abstract

Levels of plasma sialyltransferase were measured in a patient with disseminated carcinoma of the testes. Initial enzyme values, elevated six fold above those in normal controls, were among the highest thus far encountered in a population of patients with various stages and types of malignancy. During a remarkable respose to chemotherapy with cis-diaminodichloroplatinum, plasma sialyltransferase levels fell markedly. Serial measurement of this enzyme may aid in evaluation of tumor responsiveness to therapy in patients whose disease is not readily measurable.

• Authors: D Kessel, M K Samson, P Shah, J Allen, L H Baker
• Journal: Cancer (Cancer) Vol. 38 Issue 5 Pg. 2132-4 (Nov 1976) ISSN: 0008-543X [Print] United States
• PMID: 991125 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Transferases
• Sialyltransferases
• Cisplatin

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Cisplatin (therapeutic use)
• Humans
• Male
• Remission, Spontaneous
• Sialyltransferases (blood)
• Teratoma (blood, drug therapy)
• Testicular Neoplasms (blood, drug therapy)
• Transferases (blood)