Diamond-Blackfan syndrome: lymphocyte-mediated suppression of erythropoiesis.

Abstract

Peripheral blood lymphocytes from six patients with congenital hypoplastic anemia suppressed erythroid cell formation by normal human bone marrow cells in response to erythropoietin in vitro. The results suggest that the anemia in these children has an immunologic basis.

• Authors: R Hoffman, E D Zanjani, J Vila, R Zalusky, J D Lutton, L R Wasserman
• Journal: Science (New York, N.Y.) (Science) Vol. 193 Issue 4256 Pg. 899-900 (Sep 03 1976) ISSN: 0036-8075 [Print] United States
• PMID: 986086 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adrenal Cortex Hormones
• Erythropoietin

Topics

• Adrenal Cortex Hormones (pharmacology)
• Anemia, Aplastic (blood, immunology)
• Animals
• Bone Marrow Cells
• Cell Differentiation (drug effects)
• Cricetinae
• Erythrocytes, Abnormal
• Erythropoiesis (drug effects)
• Erythropoietin
• Lymphocytes (immunology)