Abstract |
Stimulation of the saphenous nerve in the anaesthetised rat results in cutaneous neurogenic oedema formation. We have examined the effect of a tachykinin NK1 and a bradykinin B2 antagonist, and a mu- opioid agonist on plasma extravasation observed in response to two differing nerve stimulating parameters (10 V, 1 ms, 2 Hz and 25 V, 2 ms, 10 Hz). The NK1 antagonist SR140333 abolished oedema, supporting the theory that an NK1 agonist is a primary mediator of neurogenic oedema. The B2 antagonist HOE 140 had no effect, indicating a lack of involvement of B2 receptors in this response. The pre-junctionally acting mu- opioid agonist DAMGO significantly inhibited oedema formation at the 10 V, 1 ms, 2 Hz (P < 0.001), but not the 25 V, 2 ms, 10 Hz stimulation parameters. Thus a post-junctionally acting NK1 antagonist inhibited neurogenic oedema formation induced by both stimulation parameters, whilst a pre-junctionally acting mu- opioid agonist acted only at 10 V, 1 ms, 2 Hz parameters. These findings could be of interest with respect to therapeutic approaches of pathophysiological conditions which involve a neurogenic component.
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Authors | P K Towler, S D Brain |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 257
Issue 1
Pg. 5-8
(Nov 20 1998)
ISSN: 0304-3940 [Print] Ireland |
PMID | 9857952
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bradykinin Receptor Antagonists
- Enkephalins
- Neurokinin-1 Receptor Antagonists
- Peptide Fragments
- Piperidines
- Quinuclidines
- Receptor, Bradykinin B2
- Receptors, Neurokinin-1
- Receptors, Opioid, mu
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- GR 73632
- SR 140333
- Substance P
- icatibant
- Bradykinin
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Topics |
- Animals
- Bradykinin
(analogs & derivatives, therapeutic use)
- Bradykinin Receptor Antagonists
- Edema
(metabolism)
- Electric Stimulation
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Enkephalins
(therapeutic use)
- Extravasation of Diagnostic and Therapeutic Materials
(drug therapy)
- Male
- Neurogenic Inflammation
(drug therapy)
- Neurokinin-1 Receptor Antagonists
- Neurons, Afferent
(drug effects, physiology)
- Peptide Fragments
(pharmacology)
- Piperidines
(therapeutic use)
- Quinuclidines
(therapeutic use)
- Rats
- Rats, Wistar
- Receptor, Bradykinin B2
- Receptors, Neurokinin-1
(agonists)
- Receptors, Opioid, mu
(agonists)
- Substance P
(analogs & derivatives, pharmacology)
- Time Factors
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