Butyrylcholinesterase K variant and cerebral amyloid angiopathy.

Abstract

BACKGROUND AND PURPOSE:

Cholinesterases are found histochemically in the vessels affected with cerebral amyloid angiopathy (CAA). A gene for the K variant of butyrylcholinesterase (BCHE-K) may be associated with late-onset Alzheimer's disease (AD). In search of genetic risk factors for CAA, we investigated the association of BCHE-K with CAA.

METHODS:

The association between the severity of CAA and BCHE-K was investigated in 155 autopsy cases of the elderly, including 48 patients with AD.

RESULTS:

There was no significant association of BCHE-K with the severity of CAA in the total, AD, or non-AD cases. Status of the epsilon4 allele of apolipoprotein E gene did not influence the results.

CONCLUSIONS:

Our results may suggest that BCHE-K is not a definitive risk factor for CAA in the elderly, although further study with larger samples is necessary to confirm this.

• Authors: M Yamada, N Sodeyama, Y Itoh, N Suematsu, E Otomo, M Matsushita, H Mizusawa
• Journal: Stroke (Stroke) Vol. 29 Issue 12 Pg. 2488-90 (Dec 1998) ISSN: 0039-2499 [Print] United States
• PMID: 9836756 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoprotein E4
• Apolipoproteins E
• Isoenzymes
• Butyrylcholinesterase

Topics

• Aged
• Aged, 80 and over
• Alleles
• Alzheimer Disease (enzymology, genetics)
• Apolipoprotein E4
• Apolipoproteins E (genetics)
• Butyrylcholinesterase (genetics, metabolism)
• Cerebral Amyloid Angiopathy (enzymology, genetics)
• Gene Frequency
• Genetic Variation
• Humans
• Isoenzymes (metabolism)
• Middle Aged