Insulin-like growth factors - insulin-like growth factor binding protein axis and diabetic control in insulin-dependent diabetes mellitus.

Abstract

There is some evidence that insulin-like growth factors (IGFs) and/or IGF binding proteins (IGFBPs) (IGF-IGFBP axis) may be involved in glucose metabolism. The purpose of this study was to investigate the relationship between the IGF-IGFBP axis and diabetic control in subjects with insulin-dependent diabetes mellitus (IDDM). Thirty-nine subjects with IDDM without major complications (age: 5.8-30.3 years, 13 males and 26 females) participated in this study. In all subjects, the free form of IGF-I (free IGF-I), the total IGF-I (total IGF-I: free plus complexed form of IGF-I) and IGFBP-3 in serum or plasma were measured. The Z-scores of free IGF-I, total IGF-I, and IGFBP-3 were calculated. In 18 young adults with IDDM (age 18.0-30.3 years, 5 males and 13 females), IGFBP-1 in serum was also measured. In all subjects, the diabetic control parameters such as blood glucose (BS) (momentary control), 1,5-anhydro-D-glucitol (1,5 AG) (Ultrashort-term), fructosamine (short term), and glycosylated hemoglobin (HbA1) (long-term) were measured. None of the Z scores for free IGF-I, total IGF-I or IGFBP-3 had a significant correlation with BS. In young adults, IGFBP-I was correlated with BS (r=0.57, P<0.005). None of the Z scores for free IGF-I, total IGF-I or IGFBP-3 had a significant correlation with 1,5 AG, fructosamine or HbA1. In young adults, IGFBP-1 did not correlate with 1,5 AG, fructosamine or HbA1. These data suggested that the IGF-IGFBP axis did not reflect diabetic control in subjects with IDDM under treatment.

• Authors: T Hasegawa, Y Hasegawa, M Takada, F Kurimoto, Y Tsuchiya
• Journal: Endocrine journal (Endocr J) Vol. 45 Suppl Pg. S129-31 (Apr 1998) ISSN: 0918-8959 [Print] Japan
• PMID: 9790247 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Insulin-Like Growth Factor Binding Proteins
• Somatomedins
• Fructosamine
• 1,5-anhydroglucitol
• Deoxyglucose

Topics

• Adolescent
• Adult
• Blood Glucose (metabolism)
• Child
• Child, Preschool
• Deoxyglucose (blood)
• Diabetes Mellitus, Type 1 (blood, physiopathology)
• Female
• Fructosamine (blood)
• Humans
• Insulin-Like Growth Factor Binding Proteins (physiology)
• Male
• Somatomedins (physiology)