[The clinical efficacy of imipenem/cilastatin sodium in orthopedic infections and drug levels in the bone tissue].
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| Abstract |
We evaluated the clinical efficacy of imipenem/cilastatin sodium (IPM/CS--a carbapenem antibiotic) against orthopedic infections, and the drug levels of the bone tissues were determined. The clinical efficacies for 6 patients in the infection group were good in 3 cases, and fair in the other 3; giving an efficacy rate of 50%. Bacteriologically, 8 strains were isolated from patients with the infection and an eradication rate of 87.5% was obtained upon the treatment. In 39 patients that were given the drug prophylactically, no postoperative infections occurred. Mean IPM levels in the bone and the bone marrow at 1 hour after administration in 5 patients of the prophylactic group were 17.3 micrograms/ml and 5.9 micrograms/g, respectively. The ratio of concentrations the bone to those in the bone marrow was 34.6%. The results of this study suggest that IMP/CS reaches to the bone tissue providing sufficient concentrations and that the drug is efficacious for the prophylaxis and the treatment of orthopedic infections.
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| Authors | N Handa, T Kawakami, K Kitaoka, E Ueda, H Shinjou, T Shimizu, K Itou, M Iwakawa, H Yamamoto, M Ando, N Yamanaka, M Nakauchi, T Nieda, M Kondou |
| Journal | The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 50 Issue 7 Pg. 622-7 (Jul 1997) ISSN: 0368-2781 [Print] Japan |
| PMID | 9743907 (Publication Type: Case Reports, Clinical Trial, Journal Article) |
| Chemical References |
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