Rothmund-Thomson syndrome and tolerance of chemoradiotherapy.

Abstract

Rothmund-Thomson syndrome (RTS) is a rare disorder with a predisposition for cutaneous and non-cutaneous malignancy. It is speculated that ultraviolet (UV) sensitivity and deficient DNA repair may account for this predisposition and influence the tolerance of chemoradiotherapeutic management. A case is reported of the management of an RTS patient with squamous cell carcinoma of the tongue who demonstrated increased radiosensitivity and tissue intolerance to chemotherapy.

• Authors: M F Borg, I N Olver, M P Hill
• Journal: Australasian radiology (Australas Radiol) Vol. 42 Issue 3 Pg. 216-8 (Aug 1998) ISSN: 0004-8461 [Print] Australia
• PMID: 9727245 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Methotrexate

Topics

• Adult
• Antimetabolites, Antineoplastic (adverse effects, therapeutic use)
• Carcinoma, Squamous Cell (complications, drug therapy, radiotherapy)
• Female
• Humans
• Methotrexate (adverse effects, therapeutic use)
• Radiotherapy, High-Energy (adverse effects)
• Rothmund-Thomson Syndrome (complications)
• Tongue Neoplasms (complications, drug therapy, radiotherapy)