Prophylactic metoclopramide administered immediately after the induction of anesthesia has no effect on the incidence of postoperative emesis after strabismus surgery.

Abstract

OBJECTIVE:

To evaluate the efficacy of metoclopramide (0.25 mg/kg) administered IV immediately after induction of general anesthesia for the prevention of postoperative emesis in children undergoing, elective strabismus surgery.

DESIGN:

Double blind, randomized.

SETTING:

Operation-theater.

SUBJECTS AND INTERVENTIONS:

Seventy six non premedicated children of ASA class 1 and 2 were randomly allocated to receive either normal saline or metoclopramide immediately after the induction of general anesthesia. All children received a standardized similar anesthetic technique. Postoperative analgesia consisted of oral indomethacin.

RESULTS:

The incidence of postoperative emesis in the metoclopramide group was 60% versus 71% in a placebo group (p < 0.05). The incidence of severe emesis (2 or > 2 vomiting) was similar in the placebo group (34.20%) and metoclopramide group (21.05%). There were no adverse reactions like excessive sedation, extrapyramidal signs and hemodynamic depression in either placebo or metoclopramide group.

CONCLUSIONS:

Metoclopramide in a dose of 0.25 mg/kg administered intravenously prior to manipulation of eyeball is devoid of the effects but is not effective in preventing postoperative emesis in children undergoing strabismus surgery.

• Authors: D Shende, M Haldar
• Journal: Indian pediatrics (Indian Pediatr) Vol. 35 Issue 3 Pg. 237-41 (Mar 1998) ISSN: 0019-6061 [Print] India
• PMID: 9707877 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiemetics
• Metoclopramide

Topics

• Anesthesia, General (adverse effects)
• Antiemetics (administration & dosage)
• Chi-Square Distribution
• Child
• Child, Preschool
• Double-Blind Method
• Drug Administration Schedule
• Elective Surgical Procedures
• Female
• Humans
• Incidence
• Injections, Intravenous
• Male
• Metoclopramide (administration & dosage)
• Premedication
• Severity of Illness Index
• Strabismus (surgery)
• Time Factors
• Treatment Outcome
• Vomiting (epidemiology, etiology, prevention & control)