Protective effects of the new lazaroid "U-83836E" in splanchnic artery occlusion (SAO) shock.

Abstract

We studied the effects of the new antioxidant drug U-83836E during splanchnic artery occlusion (SAO) shock in the rat. Serum tumor necrosis factor (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure (MAP), survival rate and the responsiveness to acetylcholine of aortic rings were investigated. SAO shock produced a marked increase in serum TNF-alpha (241.4 +/- 18.2 U/ml vs Not Detectable in basal), reduced MAP (51.4 +/- 4 mmHg vs 85.1 +/- 5 mmHg), survival time (80 +/- 10 min vs > 240 min), WBC count (2.8 +/- 0.4 x 10(3)/mm3 cells vs 11.7 +/- 0.9 x 10(3)/mm3 cells) and blunted the responsiveness to ACh of aortic rings (60 +/- 3% tension vs 23 +/- 4% tension). The analogue of vitamin E, U-84836E, administered at onset of reperfusion, lowered serum TNF-alpha (38.4 +/- 6.5 U/ml; p < 0.001), improved MAP (67.5 +/- 3.8 mmHg; p < 0.001), WBC count (8.9 +/- 0.6 x 10(3)/mm3; p < 0.001), and survival time (235 +/- 15 min; p < 0.001), and restored the responsiveness to ACh of aortic rings (32 +/- 3.7% tension; p < 0.001). These preliminary data suggest that this new compound could be a promising drug in shock therapy.

• Authors: G M Campo, F Squadrito, S Campo, D Altavilla, B Longoni, A Saitta, G Squadrito, A P Caputi
• Journal: Free radical research (Free Radic Res) Vol. 28 Issue 5 Pg. 477-84 (May 1998) ISSN: 1071-5762 [Print] England
• PMID: 9702528 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Chromans
• Piperazines
• Protective Agents
• Tumor Necrosis Factor-alpha
• Vasodilator Agents
• U 78517F
• Acetylcholine

Topics

• Acetylcholine (pharmacology)
• Animals
• Antioxidants (pharmacology)
• Arterial Occlusive Diseases (complications, drug therapy)
• Blood Pressure (drug effects)
• Chromans (pharmacology)
• Ischemia (prevention & control)
• Leukocyte Count (drug effects)
• Lipid Peroxidation (drug effects)
• Male
• Piperazines (pharmacology)
• Protective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Shock (etiology, prevention & control)
• Splanchnic Circulation (drug effects)
• Survival Rate
• Tumor Necrosis Factor-alpha (metabolism)
• Vasodilator Agents (pharmacology)