Abstract | BACKGROUND: METHODS: A double-blind, placebo controlled trial was performed to evaluate the clinical response to nebulized salbutamol. One hundred and fifty-six infants aged between 7 weeks and 24 months who had had an episode of wheezing and other signs and symptoms of bronchiolitis were randomized to three groups as follows: (i) nebulized salbutamol was administered to 52 patients in group I at a dose of 0.15 mg/kg in 2 mL saline; (ii) saline was nebulized to 52 patients in group II and (iii) in group III 52 patients received mist in a tent. All three groups were administered oxygen during the procedures. Treatment was repeated with the same agent after 30 min if the respiratory score was 5 or more. Respiratory rate, heart rate, oxygen saturation and presence of cyanosis, wheezing, retractions were recorded before and after each treatment. RESULTS: The decrease in the respiratory score was 5.2 +/- 1.8, 0.82 +/- 2.4 and 1.7 +/- 1.3 in group I, II and III, respectively. The decrease in group I was significantly higher than in the other groups. Heart rate was similar between groups. Oxygen saturation decreased in group I without reaching statistical significance. CONCLUSIONS:
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Authors | D Can, G Inan, G Yendur, R Oral, I Günay |
Journal | Acta paediatrica Japonica : Overseas edition
(Acta Paediatr Jpn)
Vol. 40
Issue 3
Pg. 252-5
(Jun 1998)
ISSN: 0374-5600 [Print] Australia |
PMID | 9695300
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Bronchodilator Agents
- Albuterol
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Topics |
- Albuterol
(therapeutic use)
- Analysis of Variance
- Bronchiolitis
(drug therapy)
- Bronchodilator Agents
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Infant
- Male
- Respiratory Therapy
(methods)
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