Detecting experimental liver metastases at CT with the hepatocyte-specific contrast medium FP 736-03.

Abstract

PURPOSE:

To evaluate the detection of experimental hepatic metastases at CT with the hepatocyte-specific contrast medium FP 736-03.

MATERIAL AND METHODS:

A nude-rat model of experimental multiple hepatic metastases from a human colonic cancer was used. Three weeks after intraportal tumour cell injection, the CT examination was performed before and after i.v. injection of FP 736-03 at a dose of 0.5 ml/kg b.w.

RESULTS:

The overall detection rate was determined in a lesion-by-lesion analysis of 87 metastases. Irrespective of metastatic size, the mean detection rate for two viewers was significantly higher at the FP-736-03-enhanced examination (59%) than at the unenhanced CT examination (16%).

CONCLUSION:

The detection rate increased with the i.v. administration of FP 736-03 at a dose of 0.5 ml/kg b.w. compared with that at unenhanced examination.

• Authors: A Bergman, A Magnusson, A Sundin
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 39 Issue 4 Pg. 381-3 (Jul 1998) ISSN: 0284-1851 [Print] England
• PMID: 9685823 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Emulsions
• Fat Emulsions, Intravenous
• Phospholipids
• iodized oil, phospholipid, cholesterol emulsion
• Iodized Oil
• Cholesterol

Topics

• Adenocarcinoma (diagnostic imaging, secondary)
• Animals
• Cholesterol
• Contrast Media
• Drug Evaluation, Preclinical
• Emulsions
• Fat Emulsions, Intravenous
• Iodized Oil
• Liver (diagnostic imaging)
• Liver Neoplasms, Experimental (diagnostic imaging, secondary)
• Neoplasm Transplantation
• Observer Variation
• Phospholipids
• Rats
• Rats, Nude
• Tomography, X-Ray Computed (methods)
• Tumor Cells, Cultured