Bioavailability of ciprofloxacin after multiple enteral and intravenous doses in ICU patients with severe gram-negative intra-abdominal infections.

Abstract

BACKGROUND:

Few data are available on the pharmacokinetics of multiple enteral dosing of ciprofloxacin in critically ill intensive care patients and none for those with severe gram-negative intra-abdominal infections (GNIAI).

OBJECTIVE:

To determine the bioavailability of enteral ciprofloxacin in tube-fed intensive care patients with severe GNIAI.

DESIGN:

A randomized crossover study.

SETTING:

University-based medical center.

PATIENTS:

5 critically ill intensive care patients with GNIAI and an estimated creatinine clearance > 25 ml/ min who received continuous tube feeding.

INTERVENTIONS:

Multiple doses of enteral 750 mg b.i.d. versus 400 mg b.i.d.i.v. ciprofloxacin.

MEASUREMENTS:

The calculated 12-h area under the serum concentration versus time curve after 750 mg b.i.d. enteral dosing was equivalent to that after 400 mg b.i.d.i.v. The mean bioavailability of enteral dosing was 53.1% [95% confidence interval (CI) 43.5-62.8]. In seven additional patients, the mean serum steady-state concentration at 2 h after enteral administration was 3.9 microg/ml (95% CI 1.9-5.9), not significantly different from that found in the crossover study (p = 0.4).

CONCLUSIONS:

In tube-fed intensive care patients with severe GNIAI, the bioavailability of enteral ciprofloxacin is adequate.

• Authors: S de Marie, M F VandenBergh, S L Buijk, H A Bruining, A van Vliet, J A Kluytmans, J W Mouton
• Journal: Intensive care medicine (Intensive Care Med) Vol. 24 Issue 4 Pg. 343-6 (Apr 1998) ISSN: 0342-4642 [Print] United States
• PMID: 9609412 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Ciprofloxacin
• Creatinine

Topics

• Adult
• Aged
• Anti-Infective Agents (administration & dosage, pharmacokinetics)
• Biological Availability
• Ciprofloxacin (administration & dosage, pharmacokinetics)
• Creatinine (blood)
• Critical Care
• Critical Illness
• Cross-Over Studies
• Drug Monitoring
• Enteral Nutrition
• Gram-Negative Bacterial Infections (drug therapy, metabolism)
• Humans
• Infusions, Intravenous
• Middle Aged
• Peritonitis (drug therapy, metabolism)