The purpose of this clinical trial is to evaluate the efficacy and safety of
fleroxacin and to compare with those of
lomefloxacin. A randomized controlled study was carried out to treat sixty patients with urinary tract and respiratory tract
bacterial infections, thirty in each group with one of the two drugs, and fifty cases were treated with
fleroxacin in an open trial. Altogether there were one hundred and ten cases. Both
fleroxacin and
lomefloxacin were given orally, the dosage was 200 mg every 12 hours or 400 mg every 24 hours for 7-14 days. The clinical efficacy rate was 93.3%; the culturing rate in the
fleroxacin group was 83.3%; the bacterial clearance rate was 92.3%, the incidence of adverse reactions was 9.4%, while in the
lomefloxacin group they were 90.0%, 80.0%, 87.5% and 6.7% respectively, with no statistically significant difference between the two groups (P > 0.05). In the open and randomized trials,
fleroxacin cured eighty cases of
bacterial infections, the overall clinical efficacy rate was 90.0%, the culturing rate in the flero-xacin group was 83.8%, the bacterial clearance rate was 88.2% and the incidence of adverse reactions was 9.6%. It is shown that
fleroxacin is an
antibiotic of broad-spectrum, high efficacy and safety.