[In vitro study on effect of body weight on deiodination of L-diiodotyrosine and L-thyroxine in liver and kidney of rats on standard diets].

Abstract

The effect of body weight on the deiodination of L-di-iodotyrosine and L-thyroxin in the liver and kidney was studied in vitro in male Wistar rats of same age, but differing in weight (light and heavy, respectively), which were fed a standard diet. In the livers of the heavy animals, the deiodination of L-di-iodotyrosine and L-thyroxin was significantly lower than in those of the light animals. As to the kidneys, no such difference was observed. From a comparison with literature data it is concluded that the reduction in deiodination in the livers of the heavy animals might be due to a reduction in thyroid hormone metabolism.

• Authors: C H Voss, K Pflugradt, G Hübner
• Journal: Die Nahrung (Nahrung) Vol. 20 Issue 1 Pg. 57-61 ( 1976) ISSN: 0027-769X [Print] Germany
• Vernacular Title: Einfluss des Körpergewichts auf die Dejodierung von L-Dijodtyrosin und L-Thyroxin in Leber und Niere in vitro bei Ratten unter Standardfutter
• PMID: 958320 (Publication Type: English Abstract, Journal Article)

Chemical References

• Diiodotyrosine
• Iodine
• Thyroxine

Topics

• Age Factors
• Animals
• Body Weight
• Diiodotyrosine (metabolism)
• Iodine (metabolism)
• Kidney (metabolism)
• Liver (metabolism)
• Male
• Organ Size
• Rats
• Thyroxine (metabolism)