[Efficacy of moxonidine, an imidazoline receptor agonist, in patients with essential hypertension].

Abstract

AIM:

Study of zint (moxonidine), a hypotensive drug with the central mechanism of action.

MATERIALS AND METHODS:

The hemodynamics and platelet functional activity were assessed in 30 patients with essential hypertension treated by zint in a daily dose of 0.4 mg, taken in the morning, for 3 months.

RESULTS:

By the end of treatment the systolic arterial pressure decreased by 23 +/- 4 mm Hg, diastolic by 15 +/- mm Hg, mean pressure by 17 +/- 2 mm Hg, and heart rate by 5 +/- 4 str/min. Echography showed that myocardial hypertrophy decreased but negligibly. An evident decrease of ADP-induced platelet aggregation was observed.

CONCLUSION:

Zint therapy may be a most physiological method of arterial hypertension control.

• Authors: E V Baliakina, I F Patrusheva, E E Rynskova, A P Iurenev
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 70 Issue 1 Pg. 15-9 ( 1998) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Opyt primeneniia agonista imidazolinovykh retseptorov moksonidina u bol'nykh gipertonicheskoĭ bolezn'iu (sobstvennoe nabliudenie).
• PMID: 9532644 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Imidazoles
• Imidazoline Receptors
• Platelet Aggregation Inhibitors
• Receptors, Drug
• moxonidine

Topics

• Adult
• Antihypertensive Agents (administration & dosage, therapeutic use)
• Blood Pressure (drug effects)
• Dose-Response Relationship, Drug
• Echocardiography
• Follow-Up Studies
• Humans
• Hypertension (blood, drug therapy, physiopathology)
• Hypertrophy, Left Ventricular (diagnostic imaging, drug therapy)
• Imidazoles (administration & dosage, therapeutic use)
• Imidazoline Receptors
• Middle Aged
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (administration & dosage, therapeutic use)
• Receptors, Drug (agonists)
• Treatment Outcome