Efficacy of gemcitabine in the treatment of patients with gallbladder carcinoma: a case report.

Abstract

BACKGROUND:

Advanced carcinoma of the gallbladder typically is unresponsive to chemotherapy, and patients with progressive metastatic disease have a short survival.

METHODS:

A patient with advanced metastatic carcinoma of the gallbladder causing peritoneal carcinomatosis and hepatic metastases is reported. This patient achieved a dramatic remission with gemcitabine after failing two other chemotherapeutic regimens.

RESULTS:

Response included reversal of complete small bowel obstruction with resumption of the ability to eat and the disappearance of liver metastases.

CONCLUSIONS:

Gemcitabine appears to be worthy of organized clinical trials in patients with this notoriously chemotherapy-resistant malignancy.

• Authors: M P Castro
• Journal: Cancer (Cancer) Vol. 82 Issue 4 Pg. 639-41 (Feb 15 1998) ISSN: 0008-543X [Print] United States
• PMID: 9477094 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Deoxycytidine
• Gemcitabine

Topics

• Adult
• Antimetabolites, Antineoplastic (therapeutic use)
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Female
• Gallbladder Neoplasms (drug therapy, pathology)
• Humans
• Krukenberg Tumor (drug therapy, secondary)
• Liver Neoplasms (drug therapy, secondary)
• Peritoneal Neoplasms (drug therapy, secondary)
• Tomography, X-Ray Computed
• Gemcitabine