[Recent data on the treatment of bovine hypodermyiasis using metrifonate (Neguvon) and ivermectin (Ivomec) in microdoses].

Abstract

Large scale preventive treatments against bovine hypodermosis have been performed in the Canton of Grisons and in different Jura areas. Either Metrifonate (Neguvon 10% spot-on, Bayer AG) or Ivermectin "microdoses" (i.e. 0.1 ml Ivomec ad. inj-MSD AGVET-per animal) have been applied. The treatment of dairy cows with Neguvon at the then recommended dose (24 ml/animal) showed a low efficacy of 80%, without any correlation to the date of treatment. An increase of the dose to 36 ml/animal revealed an efficacy of 93%, while a weight-dependent dose of 6 ml/100 kg body weight reduced the warble infestation by 97.3% without any drug-related side-effects. The few observed side-effects-salivation and mild meteorism--are likely to be due to the destruction of Hypoderma lineatum larvae in the gullet of treated cows. No case of abortion was reported. The Ivomec--"microdose" applied to young animals or dry cows showed an efficacy > 99.8%. The available drugs would thus allow a quick and efficacious control of bovine hypodermosis, provided they would be used systematically and at an appropriate dose in endemic areas.

• Authors: J L Charbon, K Pfister
• Journal: Schweizer Archiv fur Tierheilkunde (Schweiz Arch Tierheilkd) Vol. 139 Issue 12 Pg. 550-7 ( 1997) ISSN: 0036-7281 [Print] Switzerland
• Vernacular Title: Données récentes sur le traitement de l'hypodermose bovine au moyen de métrifonate (Neguvon) et d'ivermectine (Ivomec) en microdoses.
• PMID: 9451918 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Ivermectin
• Trichlorfon

Topics

• Animals
• Cattle
• Cattle Diseases (drug therapy)
• Female
• Hypodermyiasis (drug therapy, veterinary)
• Insecticides (administration & dosage, therapeutic use)
• Ivermectin (administration & dosage, therapeutic use)
• Trichlorfon (administration & dosage, therapeutic use)