Ecabapide, a novel gastroprokinetic agent, ameliorates gastric emptying of stroke-prone spontaneously hypertensive rats (SHRSP).

Abstract

The effect of ecabapide, a novel gastroprokinetic agent, on gastric emptying was examined in stroke-prone spontaneously hypertensive rats (SHRSP), which are known to exhibit gastric malfunctions as a result of autonomic nervous system disorder. Ecabapide was administered orally to SHRSP in various dose-regimens. Gastric emptying was evaluated by the acetaminophen (APAP) method using semi-solid meal under the conscious conditions. Ecabapide significantly enhanced gastric emptying of SHRSP at 1 mg/kg in single administration, 0.3 and 1 mg/kg in 2-week treatment and 7.7 mg/kg in 4-week (diet) exposure. These results suggest that the effect of ecabapide is exerted without showing tachyphylaxis.

• Authors: K Furuhama
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 59 Issue 12 Pg. 1153-5 (Dec 1997) ISSN: 0916-7250 [Print] Japan
• PMID: 9450247 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Non-Narcotic
• Anti-Ulcer Agents
• Benzamides
• Acetaminophen
• ecabapide

Topics

• Acetaminophen (pharmacology)
• Administration, Oral
• Analgesics, Non-Narcotic (pharmacology)
• Animals
• Anti-Ulcer Agents (administration & dosage, pharmacology)
• Autonomic Nervous System (physiopathology)
• Benzamides (administration & dosage, pharmacology)
• Cerebrovascular Disorders (etiology, physiopathology)
• Disease Susceptibility
• Dose-Response Relationship, Drug
• Gastric Emptying (drug effects, physiology)
• Hypertension (complications, physiopathology)
• Male
• Rats
• Rats, Inbred SHR
• Tachyphylaxis (physiology)
• Time Factors