Paradoxical hyperfixation of hexamethylpropyleneamine oxime in cerebral infarction.

Abstract	We describe four patients with cerebral infarction and 99mTc-hexamethylpropyleneamine oxime (HMPAO) hyperfixation in distributions corresponding to the infarctions seen at CT and/or MR imaging. Increased HMPAO extraction due to hyperpermeability across the blood-brain barrier and increased retention due to reduced back diffusion of the tracer probably accounted for the increased fractional fixation in infarcts seen in our patients.
Authors	S Shintani, S Tsuruoka, T Shiigai
Journal	AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) 1997 Nov-Dec Vol. 18 Issue 10 Pg. 1905-8 ISSN: 0195-6108 [Print] United States
PMID	9403452 (Publication Type: Case Reports, Journal Article)
Chemical References	Technetium Tc 99m Exametazime
Topics	Aged Blood-Brain Barrier (physiology) Brain Mapping Cerebral Cortex (diagnostic imaging) Cerebral Infarction (blood, diagnostic imaging) Dominance, Cerebral (physiology) Female Humans Male Technetium Tc 99m Exametazime (pharmacokinetics) Tomography, Emission-Computed, Single-Photon

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