Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

Abstract

4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

• Authors: M A Lovell, W D Ehmann, M P Mattson, W R Markesbery
• Journal: Neurobiology of aging (Neurobiol Aging) 1997 Sep-Oct Vol. 18 Issue 5 Pg. 457-61 ISSN: 0197-4580 [Print] United States
• PMID: 9390770 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Aldehydes
• Cysteine Proteinase Inhibitors
• Nerve Tissue Proteins
• 4-hydroxy-2-nonenal

Topics

• Aged
• Aged, 80 and over
• Aldehydes (chemistry, metabolism)
• Alzheimer Disease (metabolism)
• Body Fluids (chemistry)
• Cerebral Ventricles (chemistry, metabolism)
• Chromatography, High Pressure Liquid
• Cysteine Proteinase Inhibitors (chemistry, metabolism)
• Female
• Humans
• Lipid Peroxidation
• Male
• Middle Aged
• Nerve Tissue Proteins (metabolism)