[The effect of nifedipine on the microcirculation in pregnancy-induced hypertension].

Abstract

OBJECTIVES:

To study the effects of nifedipine on the microcirculation in pregnancy-induced hypertension (PIH).

METHODS:

We observed the microcirculation in nailfold of 30 normal pregnant women and 76 cases of PIH. 20 mg nifedipine was given and nailfold microcirculation was observed after 30 minutes.

RESULTS:

Nifedipine increased the velocity of blood flow, reduced the aggregation of erythrocytes, and dilated capillaries. After the administration of nifedipine, the total score of the nailfold microcirculation decreased significantly in mild and moderate PIH (P < 0.05), but no marked difference was observed in severe PIH cases (P > 0.05).

CONCLUSION:

The disorder of the microcirculation of PIH can be improved by nifedipine.

• Authors: C Hao, X Yu, F Li
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 31 Issue 11 Pg. 673-5 (Nov 1996) ISSN: 0529-567X [Print] China
• PMID: 9387529 (Publication Type: English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Nifedipine

Topics

• Adult
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology, therapeutic use)
• Female
• Humans
• Microcirculation (drug effects)
• Nails (blood supply)
• Nifedipine (pharmacology, therapeutic use)
• Pre-Eclampsia (drug therapy)
• Pregnancy