Treatment of uterine leiomyomas with luteinizing hormone-releasing hormone antagonist Cetrorelix.

Abstract

The efficacy of the luteinizing hormone-releasing hormone antagonist Cetrorelix (SB-75) in the medical management of uterine leiomyomas (fibromas) was evaluated. Cetrorelix was administered to 18 pre-menopausal women with myomas with a mean age of 33.3 years, who had been candidates for hysterectomy. The initial dose of Cetrorelix was 5 mg twice daily s.c. for the first 2 days and thereafter 0.8 mg was given twice daily s.c. for at least 3 months. The mean duration of the treatment was 4.4 months. Before the therapy with Cetrorelix, the mean uterine volume, measured by ultrasonography, was 395.4 +/- 69.2 ml (range 89-1166). Sixteen patients showed a progressive reduction in uterine volume from 410.4 +/- 77.1 to a mean of 230.8 +/- 52.6 ml at 3 months. All patients became amenorrhoeic and had hot flushes. After treatment with Cetrorelix, a surgical myomectomy was performed in 12 women. One of the patients subjected to myomectomy after therapy with Cetrorelix became pregnant. These patients have been followed for up to 25 months and only in one case has the uterine volume increased after therapy. Three patients had good responses to therapy with Cetrorelix and it was decided to follow them only by observation. One patient became pregnant 2 months later. In the other patient, the uterine volume remained unchanged for the duration of the follow-up of 2 years and the third patient showed an increase after 21 months. In three patients, it was necessary to perform total hysterectomy. In 14 patients, serum concentrations of luteinizing hormone, follicle stimulating hormone and oestradiol decreased after the administration of the first dose of Cetrorelix and continued at subnormal values throughout therapy. In 15 patients who were not subjected to total hysterectomy, menstrual function returned at 1 month after cessation of treatment. Overall results support the use of Cetrorelix for the management of uterine leiomyomas.

• Authors: D Gonzalez-Barcena, R B Alvarez, E P Ochoa, I C Cornejo, A M Comaru-Schally, A V Schally, J Engel, T Reissmann, H Riethmüller-Winzen
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 12 Issue 9 Pg. 2028-35 (Sep 1997) ISSN: 0268-1161 [Print] England
• PMID: 9363724 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Hormone Antagonists
• Gonadotropin-Releasing Hormone
• cetrorelix

Topics

• Adult
• Female
• Follicular Phase
• Gonadotropin-Releasing Hormone (administration & dosage, analogs & derivatives, antagonists & inhibitors, therapeutic use)
• Hormone Antagonists (therapeutic use)
• Humans
• Hysterectomy
• Leiomyoma (diagnostic imaging, drug therapy, surgery)
• Luteal Phase
• Middle Aged
• Pregnancy
• Ultrasonography
• Uterine Hemorrhage
• Uterine Neoplasms (diagnostic imaging, drug therapy, surgery)
• Uterus (diagnostic imaging)