The most appropriate time for administration was studied based on examination of the total number of leukocytes, differential white blood count, and the number of platelets in 30 cases in which 200 micrograms
Romurtide (Nopia) was injected subcutaneously on the day of
radiotherapy, 5 times a week, for 2 weeks, totally 10 times because
leukopenia was caused during treatment with
radiotherapy. It was recognized that the number of leukocytes, mainly neutrophils, increased from 1 week after starting administration of
Romurtide to after the completion of administration (2 weeks after administration), except 1 week after completion of administration. The increasing effect in the number of platelets was not recognized, and it had decreased from at the completion of administration to 1 week after the completion of administration of
Romurtide. The rate of completion of
radiotherapy was 100% without any serious adverse events, but there were 4 cases in which
fever was observed. Therefore, it is not very favorable to administer
Romurtide immediately after radiation, taking account of the treatment period of
radiotherapy. It is also considered that it would be necessary to start radiation after sufficient recovery of the number of leukocytes or increase in their number by using
G-CSF preparation in cases in which the leukocyte count has fallen since starting radiation due to the influence of the preceding
chemotherapy.