Abstract |
In order to quantify the tremorine and cold tremor activity in unanesthetized rats, a new ultrasonic motion transducer method was used. Both kinds of activity are reported as vibratory body motion that occurred between 18-32 Hz as determined by spectral analysis. The recorded signal was analyzed and its power spectrum was obtained through a fast Fourier transform operation. It was found that a negative linear relation occurs between shiver amplitude and ambient temperature (r = 0.999). A negative linear relation also occurs between metabolic rate and ambient temperature (r = 0.997). In addition, a positive linear relation between metabolic rate and cold shiver exists (r = 0.999). Both tremorine (30 mg/kg, i.p.) and cold tremor (Ta = 2-22 degrees C) activity monitored by the ultrasonic method were completely abolished by premedication with 1 mg/kg atropine. Thus, it appears that the advantages of this tremor detection method are that is non-invasive and non-contact. Therefore, the ultrasonic method provides a good choice for quantifying tremorine and cold tremor activity in unanesthetized animals during studies of thermoregulatory physiology or motor disorders.
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Authors | C W Young, M S Young, M T Lin |
Journal | The Chinese journal of physiology
(Chin J Physiol)
Vol. 40
Issue 2
Pg. 85-90
(Jun 30 1997)
ISSN: 0304-4920 [Print] India |
PMID | 9303245
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Body Temperature Regulation
(drug effects)
- Cold Temperature
- Fourier Analysis
- Male
- Oxygen Consumption
(physiology)
- Rats
- Rats, Sprague-Dawley
- Shivering
(drug effects, physiology)
- Transducers
- Tremorine
(toxicity)
- Ultrasonics
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