Abstract | AIMS/BACKGROUND: The aim of this study was to assess quantitatively the effectiveness of hyaluronan on corneal disruption in patients with dry eye. Corneal epithelial barrier function was evaluated by measuring fluorescein permeability using a slit-lamp fluorophotometer. METHODS: RESULTS: Two weeks after treatment, hyaluronan treated right corneas showed significant corneal epithelial barrier improvement in the lower portion, compared with the pretreatment day (p < 0.025). Four weeks after treatment, the treated corneas showed significant improvement in the central corneal portion (p < 0.025) and improvement in the lower portion, compared with the pretreatment day. The untreated left corneas, on the other hand showed no improvement during the course of the study. CONCLUSION: This study suggests that hyaluronan is effective in the treatment of corneal epithelial disruption in dry eye.
|
Authors | N Yokoi, A Komuro, K Nishida, S Kinoshita |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 81
Issue 7
Pg. 533-6
(Jul 1997)
ISSN: 0007-1161 [Print] England |
PMID | 9290362
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Fluoresceins
- Ophthalmic Solutions
- Hyaluronic Acid
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Dry Eye Syndromes
(drug therapy, metabolism)
- Fluoresceins
(pharmacokinetics)
- Fluorophotometry
- Follow-Up Studies
- Humans
- Hyaluronic Acid
(therapeutic use)
- Middle Aged
- Ophthalmic Solutions
(therapeutic use)
|