[The effect of the new angiotensin-converting enzyme inhibitor moexipril on the circadian rhythms of arterial pressure in hypertension patients].

Abstract

24-hour monitoring of arterial pressure was performed before, 3 and 9 weeks after moexipril treatment (daily dose 7.5-15 mg) for mild and moderate hypertension. Of 15 patients treated 66.6% responded to the 9-week course. Adjuvant hypothiazid elevated the effect to 73.6%. Moexipril lowered mean 24-h diastolic pressure without changing the 24-h pressure curve or heart rate. Antihypertensive moexipril effect was higher in the day time. Variability of diastolic arterial pressure was lower at night.

• Authors: L I Ol'binskaia, T B Andrushchishina
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 69 Issue 3 Pg. 58-61 ( 1997) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Vliianie novogo ingibitora angiotenzinprevrashchaiushchego fermenta moéksiprila na sutochnye ritmy arterial'nogo davleniia u bol'nykh gipertonicheskoĭ bolezn'iu.
• PMID: 9229835 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Delayed-Action Preparations
• Isoquinolines
• Prodrugs
• Tetrahydroisoquinolines
• moexipril

Topics

• Angiotensin-Converting Enzyme Inhibitors (adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Circadian Rhythm (drug effects)
• Delayed-Action Preparations
• Female
• Humans
• Hypertension (drug therapy, physiopathology)
• Isoquinolines (adverse effects, therapeutic use)
• Male
• Middle Aged
• Prodrugs (adverse effects, therapeutic use)
• Tetrahydroisoquinolines
• Time Factors