[The effect of polyunsaturated fatty acids on the biochemical indices of bronchial asthma patients].

Abstract

A placebo-controlled study was made of the efficacy of diet additive of omega-3 polyunsaturated fatty acids (diet oil eiconol) in 27 patients with bronchial asthma (BA). It was found that eiconol causes qualitative changes in the disease course: severe attacks of asphyxia occurred less frequently, drug doses were reduced. Provocative tests with allergen after two-week intake of eiconol versus placebo intake showed a significant decline of late allergic response due to compitative replacement of arachidonic acid in cell membranes of inflammation cell effectors by omega-3 polyunsaturated fatty acids inhibiting production of lipid mediators of inflammation.

• Authors: K A Masuev
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 69 Issue 3 Pg. 33-5 ( 1997) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Vliianie polinenasyshchennykh kislot na nekotorye biokhimicheskie pokazateli u bol'nykh bronkhial'noĭ astmoĭ.
• PMID: 9229825 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Asthmatic Agents
• Dietary Fats, Unsaturated
• Fish Oils
• eiconol

Topics

• Anti-Asthmatic Agents (therapeutic use)
• Asthma (blood, drug therapy)
• Dietary Fats, Unsaturated (therapeutic use)
• Double-Blind Method
• Drug Evaluation
• Erythrocytes (drug effects, metabolism)
• Female
• Fish Oils (therapeutic use)
• Humans
• Lipid Peroxidation (drug effects)
• Male
• Middle Aged
• Time Factors