Abstract | BACKGROUND: Recurrence of Crohn's disease after surgery is a common occurrence, pointing to the need for a strategy to prevent recurrent disease. We report the postoperative course of 10 patients who required intestinal resections for complications related to Crohn's disease. METHODS: RESULTS: To date, none of the five patients who were placed on 6-mercaptopurine have had recurrence of their Crohn's disease (mean disease-free period 32.6 +/- 18.4 months). Among those five patients not receiving 6-mercaptopurine there have been three relapses (mean time to relapse 3.7 +/- 1.2 months). Log-rank sum analyses of Kaplan-Meier survival curves show benefit to patients receiving 6-mercaptopurine in preventing relapses after intestinal resection (p < 0.05). CONCLUSIONS:
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Authors | H A Kader, S C Raynor, R Young, S S Kaufman, J Vanderhoof, E I Ruby, D R Mack |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 25
Issue 1
Pg. 93-7
(Jul 1997)
ISSN: 0277-2116 [Print] United States |
PMID | 9226535
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Mercaptopurine
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Topics |
- Adolescent
- Adult
- Antimetabolites, Antineoplastic
(therapeutic use)
- Child
- Crohn Disease
(physiopathology, prevention & control, surgery)
- Follow-Up Studies
- Humans
- Intestines
(surgery)
- Mercaptopurine
(therapeutic use)
- Postoperative Period
- Recurrence
- Survival Analysis
- Time Factors
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