Abstract | BACKGROUND: METHODS AND RESULTS:
Ursodeoxycholic acid (Ursosan cps PRO.MED.CS) was administered to patients with PBC for a period of three years, 10-12 mg/kg/day. The investigation was completed by 13 women with a confirmed diagnosis of PBC which met clinical, laboratory and morphological criteria. During treatment marked improvement of itching was recorded, a significant drop of serum bilirubin, ALP and ALT. Changes of serum albumin levels were recorded only after three years treatment. The prothrombin time and galactose elimination capacity did not change significantly. Immunoglobulins M remained elevated and antimitochondrial antibodies were detected throughout treatment. The prognosis of the disease was evaluated by means of the Mayo score, the values of which declined significantly during the investigation. No serious side-effects were observed during treatment. CONCLUSIONS: Clinical evaluation proved beyond doubt a favourable effect of ursodeoxycholic acid on clinical and laboratory findings in PBC. Treatment should be started as soon as possible. Long-term continual administration is preferable.
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Authors | M Brodanová, F Perlík |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 136
Issue 7
Pg. 215-20
(Apr 02 1997)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Kyselina urzodeoxycholová v lécení primární biliární cirhózy. |
PMID | 9221197
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Female
- Humans
- Liver Cirrhosis, Biliary
(drug therapy)
- Middle Aged
- Prospective Studies
- Ursodeoxycholic Acid
(therapeutic use)
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