Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo.

Abstract

BACKGROUND:

Actinic prurigo (AP) is triggered by sun exposure. Its prevalence in Mexicans seems to be particularly high, which suggests a genetic susceptibility.

OBJECTIVE:

Our purpose was to determine the role of major histocompatibility complex (MHC) genes in the genetic susceptibility to AP.

METHODS:

Fifty-six Mexican Mestizo patients with AP underwent serologic typing for HLA class I and class II antigens. Class II MHC genes were also studied by DNA analysis. Findings in patients were compared with 100 ethnically matched healthy controls.

RESULTS:

We found that 92.8% of patients with AP were HLA-DR4 positive (corrected p = 0.002; odds ratio [OR] = 10.1). The class I antigens HLA-A28 and HLA-B39 (B16) were also significantly increased (p < or = 0.000001, OR = 20.9 and p = 0.0001, OR = 6.7, respectively) compared with normal controls. Allele-specific oligonucleotide DR4 subtyping showed that 80.7% of HLA-DR4+ patients with AP were also positive for the DRB1*0407 allele.

CONCLUSION:

These results confirm the role of HLA-DR4 (DRB1*0407) in the genetic susceptibility to AP and raise the possibility of a role for class I MHC antigens HLA-A28 and B16 in Mexican patients.

• Authors: T Hojyo-Tomoka, J Granados, G Vargas-Alarcón, J K Yamamoto-Furusho, E Vega-Memije, R Cortés-Franco, O Flores, F Teixeira, L Domínguez-Soto
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 36 Issue 6 Pt 1 Pg. 935-7 (Jun 1997) ISSN: 0190-9622 [Print] United States
• PMID: 9204058 (Publication Type: Journal Article)

Chemical References

• HLA-B Antigens
• HLA-DR Antigens
• Histocompatibility Antigens Class I
• Histocompatibility Antigens Class II

Topics

• Adolescent
• Adult
• Child
• Disease Susceptibility
• Ethnicity
• Female
• HLA-B Antigens (analysis)
• HLA-DR Antigens (analysis)
• Histocompatibility Antigens Class I (analysis)
• Histocompatibility Antigens Class II (analysis)
• Humans
• Indians, North American (genetics)
• Male
• Mexico
• Middle Aged
• Phenotype
• Prurigo (ethnology, etiology, genetics, immunology)
• Sunlight (adverse effects)
• White People (genetics)