Abstract | BACKGROUND: METHODS: RESULTS: Serum ACE, plasma renin activity (PRA) and p-ANP were higher in hyperthyroid rabbits and lower in hypothyroid rabbits than in euthyroid rabbits. ANP concentration in atria was lower in hyperthyroid rabbits and higher in hypothyroid rabbits than in euthyroid rabbits. p-ANP, PRA and serum ACE levels were positively correlated with serum thyroxin levels. Inverse correlation was found between serum thyroxin and ANP concentration in atria (a- ANP), and between p-ANP and a- ANP. CONCLUSIONS: Our results indicate that not only p-ANP but also serum ACE activity was markedly increased in experimental hyperthyroid rabbits. It was thought that there were both direct and indirect effects of thyroxin on the release of ANP.
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Authors | E Yeğin, R Yiğitoğlu, Z Ari, I Celik, F Akçay, H Süzek |
Journal | Japanese heart journal
(Jpn Heart J)
Vol. 38
Issue 2
Pg. 273-9
(Mar 1997)
ISSN: 0021-4868 [Print] Japan |
PMID | 9201114
(Publication Type: Journal Article)
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Chemical References |
- Atrial Natriuretic Factor
- Peptidyl-Dipeptidase A
- Renin
- Thyroxine
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Topics |
- Animals
- Atrial Natriuretic Factor
(blood)
- Blood Pressure
- Heart Rate
- Hyperthyroidism
(blood, enzymology, physiopathology)
- Hypothyroidism
(blood, enzymology, physiopathology)
- Male
- Peptidyl-Dipeptidase A
(blood)
- Rabbits
- Renin
(blood)
- Thyroxine
(blood)
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