[Triamterene in the treatment of hypertension with hydrochlorothiazide and propranolol (author's transl)].

Abstract

In 36 patients with essential hypertension the action and side effects of hydrochlorothiazide (25 mg/d), hydrochlorothiazide-triamterene (25 and 50 mg/d) and propranolol (160 mg/d) were investigated. Hydrochlorothiazide and hydrochlorothiazide-triamterene led to an average decrease of the systolic blood pressure by 21 and 30 mm Hg and of the diastolic pressure by 11 and 18 mm Hg. Propranolol alone decreased the systolic pressure by 35 mm Hg on average in 8 out of 16 patients. The diastolic pressure was lowered by 20 mm Hg. In the remaining 8 patients the systolic pressure, when propranolol was used alone, decreased by 21.3 mm Hg, the diastolic pressure by 11.3 mm Hg. Addition of hydrochlorothiazide-triamterene lowered pressures by a further 22.5 (systolic) and 10.6 (diastolic) mm Hg. No disturbances of the potassium or acid-base balance were observed using hydrochlorothiazide-triamterene.

• Authors: R Düsing, H J Kramer
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 102 Issue 43 Pg. 1541-6 (Oct 28 1977) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Triamteren in der Hochdruckbehandlung mit Hydrochlorothiazid und Propranolol.
• PMID: 913294 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Hydrochlorothiazide
• Propranolol
• Potassium
• Triamterene

Topics

• Acid-Base Equilibrium
• Adult
• Aged
• Drug Therapy, Combination
• Female
• Humans
• Hydrochlorothiazide (adverse effects, therapeutic use)
• Hypertension (drug therapy)
• Male
• Middle Aged
• Potassium (metabolism)
• Propranolol (therapeutic use)
• Time Factors
• Triamterene (therapeutic use)