Abstract | BACKGROUND: The nonpromoting effect of olive oil on colon carcinogenesis has been attributed to its high oleic acid content, whereas a positive association of monounsaturated fat in beef tallow with colon tumors has been reported. The effect of constituents other than fatty acids could not be neglected in these experiments. In order to minimize the effects of minor constituents in the oils, the authors compared conventional safflower oil with oil from a mutant strain of safflower that is rich in oleic acid. METHODS: RESULTS:
Tumor multiplicity in animals fed the HF-OA diet was indistinguishable from that in animals fed LF-LA or LF-OA. In contrast, animals fed the HF-LA diet had a significantly higher incidence of colon tumors (mostly adenocarcinomas) than the other groups. Fatty acid profiles of colon phospholipids reflected those of the diet. Animals fed a HF-LA diet showed a marked decrease of nervonic acid (C24:1, n-9) in the colon sphingomyelin. CONCLUSIONS:
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Authors | M Takeshita, H Ueda, K Shirabe, Y Higuchi, S Yoshida |
Journal | Cancer
(Cancer)
Vol. 79
Issue 8
Pg. 1487-93
(Apr 15 1997)
ISSN: 0008-543X [Print] United States |
PMID | 9118028
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Dimethylhydrazines
- Phospholipids
- Safflower Oil
- 1,2-Dimethylhydrazine
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Topics |
- 1,2-Dimethylhydrazine
- Animals
- Carcinogenicity Tests
- Carcinogens
- Colon
(chemistry)
- Colonic Neoplasms
(chemically induced, etiology)
- Dimethylhydrazines
- Eating
- Female
- Mice
- Mice, Inbred ICR
- Neoplasms, Experimental
(chemically induced, etiology)
- Phospholipids
(chemistry)
- Safflower Oil
(administration & dosage, adverse effects, chemistry)
- Weight Gain
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