Abstract | PURPOSE: To evaluate the efficacy of macular grid photocoagulation in preserving or improving central visual acuity in eyes with macular edema due to central vein occlusion (CVO) and best-corrected visual acuity of 20/50 or poorer. METHODS: Patients with angiographically documented macular edema due to CVO were entered into a multicenter randomized controlled clinical trial supported by the National Eye Institute. Eligibility was determined based on both clinical examination findings and photographic documentation evaluated at a photograph reading center. Eyes were assigned randomly to macular grid photocoagulation (77 eyes) or no treatment (78 eyes). Patients were followed every 4 months for 3 years or until the end of the study. The outcome measure was visual acuity. RESULTS: The study population consisted of 155 eyes in 155 patients. There was no difference between treated and untreated eyes in visual acuity at any point during the follow-up period. Initial median visual acuity was 20/160 in treated eyes and 20/ 125 in control eyes. Final median visual acuity was 20/200 in treated eyes and 20/160 in control eyes. However, treatment clearly reduced angiographic evidence of macular edema. CONCLUSION: The results of this study do not support a recommendation for macular grid photocoagulation for the population meeting the Central Vein Occlusion Study macular edema group eligibility criteria.
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Authors | |
Journal | Ophthalmology
(Ophthalmology)
Vol. 102
Issue 10
Pg. 1425-33
(Oct 1995)
ISSN: 0161-6420 [Print] United States |
PMID | 9097788
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Edema
(etiology, physiopathology, surgery)
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Fundus Oculi
- Humans
- Laser Coagulation
- Macula Lutea
(physiopathology, surgery)
- Male
- Middle Aged
- Photography
- Retinal Diseases
(etiology, physiopathology, surgery)
- Retinal Vein Occlusion
(complications, physiopathology)
- Treatment Outcome
- Visual Acuity
(physiology)
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