Abstract |
In an attempt to improve the success of a previous study of the prevention of neonatal hyperbilirubinemia employing phenobarbital in a single 30-mg nightly dose from 32 weeks' gestation until delivery, 246 patients were tested against 270 control subjects. A 39% reduction in significant hyperbilirubinemia was realized but this fell far short of previous findings with a larger dose. Premature infants received no apparent protection against jaundice. Mature infants had no severe jaundice (more than 16 mg/100 ml) and the resolution of hyperbilirubinemia was more rapid. No apparent difference in drowsiness or daytime sedation from previous experience was found. Female newborns responded much better (3:1) to prophylaxis. These disappointing results favor a return to the 1-g daily divided dose.
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Authors | C R Thomas |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 50
Issue 5
Pg. 607-10
(Nov 1977)
ISSN: 0029-7844 [Print] United States |
PMID | 909669
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Birth Weight
- Diseases in Twins
(epidemiology)
- Drug Administration Schedule
- Female
- Humans
- Indiana
- Infant, Newborn
- Jaundice, Neonatal
(epidemiology, prevention & control)
- Male
- Phenobarbital
(administration & dosage, therapeutic use)
- Pregnancy
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