In vitro aggregation facilities beta-amyloid peptide-(25-35)-induced amnesia in the rat.

Abstract

The beta-amyloid peptide-(25-35) fragment, but not beta-amyloid peptide-(1-28), shares with beta-amyloid protein-(1-42) the ability to self-aggregate and to induce neurotoxicity in vitro. This study examined the induction of amnesia in rats given intracerebroventricularly soluble or aggregated beta-amyloid peptide-(25-35) (5-45 nmol), or beta-amyloid peptide-(1-28) (15 nmol). Memory deficit in the water-maze test, examined 14 days after aggregated beta-amyloid peptide-(25-35) injection, was more pronounced than with soluble beta-amyloid peptide-(25-35). beta-Amyloid peptide-(1-28) only affected retention. These results confirm the direct amnesic properties of beta-amyloid peptides in the rat brain and showed that prior peptide aggregation markedly facilitates the appearance of amnesia.

• Authors: S Delobette, A Privat, T Maurice
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 319 Issue 1 Pg. 1-4 (Jan 14 1997) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9030890 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Peptide Fragments
• amyloid beta-protein (25-35)

Topics

• Amnesia (chemically induced)
• Amyloid beta-Peptides (chemistry, toxicity)
• Animals
• Injections, Intraventricular
• Male
• Maze Learning (drug effects)
• Peptide Fragments (chemistry, toxicity)
• Rats
• Rats, Wistar