Clinical outcome after one year following samarium-153 particulate hydroxyapatite radiation synovectomy.
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| Abstract |
The clinical outcome and tolerability following treatment with samarium-153 particulate hydroxyapatite was evaluated in patients with persistent rheumatoid knee synovitis. The clinical review of 18 patients treated with intra-articular samarium-153 particulate hydroxyapatite combined with triamcinolone hexacetonide who had failed to obtain more than 4 weeks symptom relief from a prior intra-articular glucocorticoid injection was undertaken. No unwanted effects from the treatment were observed. Symptom relief was maintained in 56% patients at 6 months and in 44% of patients at 12 months following treatment. Median duration of symptom relief was 9 months. There was a significantly higher mean baseline Ritchie Articular Index in patients relapsing within 3 months and a trend towards earlier relapse in patients with higher indices of disease activity at the time of treatment. There was a trend towards earlier relapse in patients with a poor range of knee flexion at baseline and with worse indices of intra-articular radiopharmaceutical distribution. Samarium-153 particulate hydroxyapatite knee synovectomy is well tolerated and may be an effective treatment for carefully selected patients with persistent rheumatoid knee synovitis.
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| Authors | G Clunie, D Lui, I Cullum, P J Ell, J C Edwards |
| Journal | Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 25 Issue 6 Pg. 360-6 ( 1996) ISSN: 0300-9742 [Print] England |
| PMID | 8996470 (Publication Type: Journal Article) |
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