Abstract |
We evaluated the efficacy of S-1 as a new oral antitumor agent in ovarian cancer-bearing nude rats. This drug consists of tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid in a molar ratio of 1:0.4:1.S-1 was given alone or in combination with cisplatin. When administered alone at a daily dose of 20 mg/ kg, S-1 produced a significant inhibition of tumor growth [inhibition rate (IR) 89%] in the treated versus the control animals (p < 0.05). The effects of S-1 resembled those of cisplatin-treated groups. The consecutive daily administration of S-1, 20 mg/kg, combined with cisplatin, 1 mg/kg, markedly inhibited cell growth (IR 99%), a significant difference relative to cisplatin alone (p < 0.05). The daily administration of S-1 combined with low-dose cisplatin induced tumor regression with a low toxicity.
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Authors | M Suzuki, I Sekiguchi, I Sato, T Shirasaka |
Journal | Chemotherapy
(Chemotherapy)
1996 Nov-Dec
Vol. 42
Issue 6
Pg. 452-8
ISSN: 0009-3157 [Print] Switzerland |
PMID | 8957580
(Publication Type: Journal Article)
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Chemical References |
- Pyridines
- Tegafur
- Oxonic Acid
- Cisplatin
- Fluorouracil
- gimeracil
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Topics |
- Administration, Oral
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use, toxicity)
- Body Weight
(drug effects)
- Cell Division
(drug effects)
- Cisplatin
(therapeutic use, toxicity)
- Female
- Fluorouracil
(blood)
- Gastrointestinal Diseases
(chemically induced)
- Neoplasm Transplantation
- Ovarian Neoplasms
(blood, drug therapy)
- Oxonic Acid
(therapeutic use, toxicity)
- Pyridines
(therapeutic use, toxicity)
- Rats
- Rats, Nude
- Tegafur
(therapeutic use, toxicity)
- Transplantation, Heterologous
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