Photosensitization by anticancer agents 21: new perylene- and aminonaphthoquinones.

Abstract

Hypocrellins are under intensive investigation as photosensitizing agents for photodynamic therapy (PDT). A recent advance in the synthesis of hypocrellin congeners resulted in the production of an amino-substituted hypocrellin-B, and its "half chromophore." Both compounds exhibit stronger red light absorption than previously reported hypocrellins, and, therefore, merit investigation as photosensitizers.

• Authors: Z J Diwu, R P Haugland, J Liu, J W Lown, G G Miller, R B Moore, K Brown, J Tulip, M S McPhee
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 20 Issue 4 Pg. 589-93 ( 1996) ISSN: 0891-5849 [Print] United States
• PMID: 8904300 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Quinones
• Phenol
• Perylene
• hypocrellin A

Topics

• Animals
• Mice
• Molecular Structure
• Neoplasms, Experimental (drug therapy)
• Perylene (analogs & derivatives, therapeutic use)
• Phenol
• Photochemotherapy
• Quinones (therapeutic use)
• Tumor Cells, Cultured