Abstract | BACKGROUND: METHODS: Two hundred and ninety-two patients with clinical symptoms of BPH were randomly allocated to one of the following treatments for 48 weeks: placebo or the selective aromatase inhibitor, atamestane, at a daily dose of 100 mg or 300 mg. Both doses of atamestane significantly reduced serum concentrations of estradiol and estrone, and produced a slight, dose-dependent, counter-regulatory increase in peripheral androgen concentration. RESULTS: Clinical symptoms improved during treatment in all three groups. Even after 48 weeks, the effect of active treatment did not exceed the effect seen with placebo. Overall tolerance of 100 mg atamestane was excellent, but 300 mg showed a slightly increased incidence of side effects compared with placebo. CONCLUSIONS:
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Authors | A Radlmaier, H U Eickenberg, M S Fletcher, R O Fourcade, J M Reis Santos, O G van Aubel, A V Bono |
Journal | The Prostate
(Prostate)
Vol. 29
Issue 4
Pg. 199-208
(Oct 1996)
ISSN: 0270-4137 [Print] United States |
PMID | 8876703
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Androgens
- Aromatase Inhibitors
- Enzyme Inhibitors
- Estrogen Antagonists
- Placebos
- Estrone
- Androstenedione
- Estradiol
- atamestane
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Topics |
- Aged
- Androgens
(blood)
- Androstenedione
(administration & dosage, analogs & derivatives, therapeutic use)
- Aromatase Inhibitors
- Dose-Response Relationship, Drug
- Double-Blind Method
- Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Estradiol
(blood)
- Estrogen Antagonists
(therapeutic use)
- Estrone
(blood)
- Humans
- Male
- Middle Aged
- Placebos
- Prostatic Hyperplasia
(drug therapy)
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