5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.

Abstract

The electrophysiologic and antifibrillatory properties of 5-hydroxydecanoate, a KATP channel antagonist, were studied in a conscious canine model of sudden cardiac death. After a surgically induced myocardial infarction, animals were subjected to programmed electrical stimulation to identify those at risk for sudden cardiac death. 5-Hydroxydecanoate was administered as a bolus (10 mg/kg i.v.) followed by an infusion, 10 mg/kg/h (group 1, n = 12) or 30 mg/kg bolus followed by an infusion, 30 mg/kg/h (group 2, n = 8) i.v., while vehicle treated animals received a 0.9% sodium chloride solution (group 3, n = 11). The administration of 5-hydroxydecanoate did not alter the ventricular effective refractory period or the QTc interval. Anterior wall myocardial infarcts, expressed as a percentage of the left ventricle, did not differ among groups. Infusions of 5-hydroxydecanoate did not confer significant protection from sudden cardiac death (death within 60 min of posterolateral ischemia) due to ventricular fibrillation: group 1, 50%; group 2, 38%; and group 3, 18%. The data demonstrate that a continuous infusion of 5-hydroxydecanoate (10 and 30 mg/kg/h, i.v.) does not provide protection from ischemia-induced ventricular fibrillation in the postinfarcted conscious canine.

• Authors: G S Friedrichs, J N Abreu, S C Black, L Chi, B R Lucchesi
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 306 Issue 1-3 Pg. 99-106 (Jun 13 1996) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8813621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-Arrhythmia Agents
• Decanoic Acids
• Hydroxy Acids
• 5-hydroxydecanoic acid

Topics

• Action Potentials (drug effects)
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Blood Pressure (drug effects)
• Death, Sudden, Cardiac (prevention & control)
• Decanoic Acids (pharmacology)
• Dogs
• Electrocardiography
• Heart Rate (drug effects)
• Hydroxy Acids (pharmacology)
• Infusions, Intravenous
• Ischemia (chemically induced)
• Male
• Myocardial Infarction (etiology)
• Ventricular Fibrillation (drug therapy, prevention & control)