Cyclic Cushing's disease in long-term remission with a daily low dose of bromocriptine.

Abstract

A 56-year-old male patient with cyclic Cushing's disease remained in a state of remission for more than one year with a relatively low dose of bromocriptine (2.5-3.75 mg/day). It has been reported that bromocriptine treatment for cyclic Cushing's disease induces only a transient remission; in the most effective cases, a relatively high dose (40 mg/day) was necessary. In the hypercortisolemic state, plasma adrenocorticotropic hormone (ACTH) and serum cortisol were not suppressed by dexamethasone and did not respond to corticotropin-releasing factor (CRF). An antehypophysectomy was not effective, even though the resected tissue contained ACTH-positive microadenomas. The present observations thus indicate the effectiveness of bromocriptine for some patients with this rare disorder.

• Authors: M Adachi, R Takayanagi, T Yanase, Y Sakai, S Ikuyama, H Nakagaki, Y Osamura, N Sanno, H Nawata
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 35 Issue 3 Pg. 207-11 (Mar 1996) ISSN: 0918-2918 [Print] Japan
• PMID: 8785455 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dopamine Antagonists
• Bromocriptine
• Adrenocorticotropic Hormone
• Hydrocortisone

Topics

• Adenoma (pathology, surgery)
• Adrenocorticotropic Hormone (antagonists & inhibitors, blood)
• Bromocriptine (administration & dosage, therapeutic use)
• Cushing Syndrome (blood, drug therapy, pathology)
• Dopamine Antagonists (administration & dosage, therapeutic use)
• Humans
• Hydrocortisone (antagonists & inhibitors, blood)
• Hypophysectomy
• Male
• Middle Aged
• Periodicity
• Pituitary Neoplasms (pathology, surgery)
• Recurrence
• Remission Induction (methods)