Abstract |
The relationship between symptoms of premenstrual syndrome (PMS) and serum levels of pregnenolone (Pe), pregnenolone sulfate ( PS), 5 alpha-pregnane-3,20-dione (5 alpha-DHP), 3 alpha-hydroxy-5 alpha- pregnan-20-one (5 alpha-THP), LH, 17 beta-estradiol (E2), and progesterone (P) was investigated during 2 consecutive menstrual cycles in 12 patients using daily measurements. Corresponding hormones were also measured during 1 cycle in 8 control women. Pe, PS, 5 alpha-DHP, and 5 alpha-THP showed a significant cyclicity within menstrual cycles and a high rate of correlation with P variation in both PMS patients and controls. No significant difference was found between PMS patients and controls in average serum concentrations of Pe, PS, 5 alpha-DHP, 5 alpha-THP, and LH during the luteal phase, whereas a significantly higher level of E2 and a lower level of P were observed in PMS patients. The variation in symptom scores was compared with that in hormone levels within each woman. The symptom peak showed a delay of 3-4 days after the serum P, Pe, 5 alpha-DHP, and 5 alpha-THP peaks. However, the plasma PS peak appeared on the same day or only 1 day before the symptom peak in PMS patients. When comparing the 2 cycles studied, more negative symptoms occurred in cycles with higher luteal phase E2, Pe, and PS concentrations, whereas higher luteal phase 5 alpha-DHP and 5 alpha-THP concentrations were associated with improved symptom ratings in PMS patients. These results suggest that the mentioned steroids are related to the severity of distressing symptoms in PMS patients.
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Authors | M Wang, L Seippel, R H Purdy, T Bãckström |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 81
Issue 3
Pg. 1076-82
(Mar 1996)
ISSN: 0021-972X [Print] United States |
PMID | 8772579
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hormones
- Pregnanediones
- pregnenolone sulfate
- Pregnenolone
- 5-alpha-Dihydroprogesterone
- Pregnanolone
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Topics |
- 5-alpha-Dihydroprogesterone
- Adult
- Female
- Hormones
(blood)
- Humans
- Luteal Phase
(blood)
- Menstrual Cycle
(blood)
- Osmolar Concentration
- Pregnanediones
(blood)
- Pregnanolone
(blood)
- Pregnenolone
(blood)
- Premenstrual Syndrome
(blood, physiopathology)
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