Mechanisms behind changes in gastric acid and bicarbonate outputs during the human interdigestive motility cycle.
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| Abstract |
Human gastric interdigestive acid and bicarbonate outputs vary cyclically in association with the migrating motor complex (MMC). These phenomena were studied in 26 healthy volunteers by constant-flow gastric perfusion, with continuous recording of pH and Pco2 in mixed gastric effluent and concomitant open-tip manometry of gastroduodenal motility. Stable acid and bicarbonate outputs were registered during less than 50% of the MMC cycle. Acid secretion started to increase 71 +/- 3% into the cycle, with maximum output during antral phase III. Bicarbonate output increased biphasically 1) 40 +/- 5% into the cycle, coinciding with reflux of bile, and 2) at the end of duodenal phase III when the aspirate was devoid of bile. The bicarbonate peak associated with phase III was abolished by atropine (0.01 mg/kg iv, n = 8) and by pyloric occlusion (n = 9) but remained unchanged after omeprazole (n = 10). The acid peak was abolished by both atropine and omeprazole. It is concluded that the MMC-related changes in acid and alkaline outputs represent two different and independent phenomena. Acid secretion cyclicity is due to periodical variations in cholinergic stimulation of the parietal cells. In contrast, the phase III-associated increase in bicarbonate output is due to duodenogastric reflux.
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| Authors | J Dalenbäck, L Fändriks, L Olbe, H Sjövall |
| Journal | The American journal of physiology (Am J Physiol) Vol. 270 Issue 1 Pt 1 Pg. G113-22 (Jan 1996) ISSN: 0002-9513 [Print] United States |
| PMID | 8772508 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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