[Hyperhomocyst(e)inemia--an independent risk factor of stroke].

Abstract

The total of free and protein-bound homocysteine including its derivatives is usually summarised as "homocyst(e)ine [H(e)]". Several congenital enzyme deficiencies may cause markedly elevated H(e) plasma levels, leading to the well-known clinical syndromes of homocystinuria. Recently, mild hyperhomocyst(e)inemia has been recognised as an independent risk factor for ischaemic cerebrovascular disease, coronary heart disease, and peripheral artery disease. H(e) levels are also related to the extent of atherosclerotic vessel wall alterations. The role of mild hyperhomocyst(e)inemia in venous thromboembolic disease, however, is not yet clear. A considerable proportion of patients with mild hyperhomocyst(e)inemia suffers from a deficiency of folate, vitamin B12, and/or vitamin B6. Supplementation of these agents--alone or combined with betain--leads to a decrease or even to a normalisation of elevated H(e) levels in the majority of such patients. Hitherto, no prospective randomised studies dealing with the clinical efficacy of such a--probably innocuous--supplementation have been performed. In the meantime, adequate alimentary intake of folate should be ensured.

• Authors: W Lalouschek, S Aull, L Deecke, P Schnider, F Uhl, K Zeiler
• Journal: Fortschritte der Neurologie-Psychiatrie (Fortschr Neurol Psychiatr) Vol. 64 Issue 7 Pg. 271-7 (Jul 1996) ISSN: 0720-4299 [Print] Germany
• Vernacular Title: Hyperhomocyst(e)inämie--ein unabhängiger Risikofaktor des Schlaganfalls.
• PMID: 8765893 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Homocysteine
• Homocystine

Topics

• Amino Acid Metabolism, Inborn Errors (blood)
• Arterial Occlusive Diseases (blood)
• Cerebrovascular Disorders (blood)
• Coronary Disease (blood)
• Homocysteine (blood)
• Homocystine (blood)
• Humans
• Risk Factors